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Loxl1 Lysyl oxidase-like 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43712, updated on 4-Jan-2025

Summary

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Official Symbol
Loxl1provided by FlyBase
Official Full Name
Lysyl oxidase-like 1provided by FlyBase
Primary source
FLYBASE:FBgn0039848
Locus tag
Dmel_CG11335
See related
AllianceGenome:FB:FBgn0039848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11335; Dmel\CG11335; dmlox-1; Dmloxl-1; DmLOXL-1; DmLOXL1; lox; Lox; LOX
Summary
Enables copper ion binding activity and protein-lysine 6-oxidase activity. Predicted to be involved in protein modification process. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in organism. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL2 (lysyl oxidase like 2) and LOXL3 (lysyl oxidase like 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Loxl1 in Genome Data Viewer
Location:
100C4-100C4; 3-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31458380..31459869, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27284102..27285591, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gcn2 Neighboring gene Polynucleotide phosphorylase Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45554 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Formation of lysine tyrosylquinone (LTQ) is a self-processing reaction. Expression and characterization of a Drosophila lysyl oxidase. Bollinger JA, et al. Biochemistry, 2005 Sep 6. PMID 16128571
  2. Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase. Rao G, et al. Biochemistry, 2017 Jul 25. PMID 28660757
  3. Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development. Molnar J, et al. J Biol Chem, 2005 Jun 17. PMID 15811848
  4. Regulation of the collagen IV network by the basement membrane protein perlecan is crucial for squamous epithelial cell morphogenesis and organ architecture. Bonche R, et al. Matrix Biol, 2022 Dec. PMID 36343860
  5. Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. Stramer B, et al. EMBO Rep, 2008 May. PMID 18344972, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. possible interactions between the LOX inhibitor BAPN (beta-aminopropionitrile; 1-[(13)C(15)N]cyano-2-aminoethane) and the copper center-finding none.
    Title: Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
  2. Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
    Title: Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development.
  3. cofactor in the active, copper-containing enzyme is lysine tyrosylquinone (LTQ); LTQ biogenesis most likely occurs by self-processing chemistry, requiring only the precursor protein, copper, and oxygen
    Title: The Formation of lysine tyrosylquinone (LTQ) is a self-processing reaction. Expression and characterization of a Drosophila lysyl oxidase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine 6-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine 6-oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine 6-oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein modification process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysyl oxidase-like 1
Names
CG11335-PA
Loxl1-PA
lysyl oxidase
lysyl oxidase-like
lysyl oxidase-like protein L1
NP_524607.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31458380..31459869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079868.3 → NP_524607.1  lysyl oxidase-like 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524607.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PV29, Q9V9X5
    Related
    FBpp0085171
    Conserved Domains (3) summary
    smart00202
    Location:50 → 136
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:50 → 137
    SRCR; Scavenger receptor cysteine-rich domain
    pfam01186
    Location:149 → 343
    Lysyl_oxidase; Lysyl oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9X5 Q9V9X5

Gene LinkOut

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