tk2 thymidine kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tk2provided by ZNC
Official Full Name: thymidine kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-243
See related: Ensembl:ENSDARG00000046127 AllianceGenome:ZFIN:ZDB-GENE-040718-243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:100948
Summary: Predicted to enable deoxynucleoside kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be active in mitochondrion. Is expressed in exocrine pancreas and pectoral fin. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (44599313..44605086, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (44260088..44265872, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables deoxynucleoside kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables thymidine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thymidine kinase 2, mitochondrial

NP_001002743.2

EC 2.7.1.21

XP_068078327.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002743.2 → NP_001002743.2 thymidine kinase 2, mitochondrial

Status: VALIDATED

Source sequence(s)

CT027744

UniProtKB/TrEMBL

A0A8M1N0Z5, F8W4G9

Related

ENSDARP00000124191.2, ENSDART00000148471.4

Conserved Domains (1) summary

pfam01712
Location:62 → 265

dNK; Deoxynucleoside kinase