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slc2a3a solute carrier family 2 member 3a [ Danio rerio (zebrafish) ]

Gene ID: 436916, updated on 4-Jan-2025

Summary

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Official Symbol
slc2a3aprovided by ZNC
Official Full Name
solute carrier family 2 member 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-390
See related
Ensembl:ENSDARG00000013295 AllianceGenome:ZFIN:ZDB-GENE-040718-390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
glut3a; slc2a3; zgc:92476; wu:fb92c06
Summary
Predicted to enable transmembrane transporter activity. Acts upstream of or within brain development. Predicted to be located in membrane. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and spinal cord neural tube. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See slc2a3a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9685209..9712482, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9766287..9794300, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 1a Neighboring gene serine/threonine/tyrosine kinase 1a Neighboring gene uncharacterized LOC137488432 Neighboring gene si:dkey-14o18.2 Neighboring gene calcium channel, voltage-dependent, gamma subunit 6a Neighboring gene uncharacterized LOC108180147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. GLUT3 gene expression is critical for embryonic growth, brain development and survival. Carayannopoulos MO, et al. Mol Genet Metab, 2014 Apr. PMID 24529979, Free PMC Article
  2. Hyperglycemia induces memory impairment linked to increased acetylcholinesterase activity in zebrafish (Danio rerio). Capiotti KM, et al. Behav Brain Res, 2014 Nov 1. PMID 25157430
  3. Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo. Zheng PP, et al. Ann Neurol, 2010 Dec. PMID 21194153
  4. An Association between Insulin Resistance and Neurodegeneration in Zebrafish Larval Model (Danio rerio). Md Razip NN, et al. Int J Mol Sci, 2022 Jul 27. PMID 35955446, Free PMC Article
  5. Glucose metabolism is required for oocyte maturation of zebrafish. Kang T, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33945997

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 3a
Names
solute carrier family 2 (facilitated glucose transporter), member 3
solute carrier family 2 (facilitated glucose transporter), member 3a
zglut3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002643.1 → NP_001002643.1  solute carrier family 2, facilitated glucose transporter member 3a

    See identical proteins and their annotated locations for NP_001002643.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076560
    UniProtKB/TrEMBL
    A0A8M2B5Y6, Q6DFZ5
    Related
    ENSDARP00000015253.5, ENSDART00000016197.7
    Conserved Domains (2) summary
    cd06174
    Location:66 → 432
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 466
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    9685209..9712482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159426.5 → XP_005159483.1  solute carrier family 2, facilitated glucose transporter member 3a isoform X2

    See identical proteins and their annotated locations for XP_005159483.1

    UniProtKB/TrEMBL
    A0A8M2B5Y6, Q6DFZ5
    Related
    ENSDARP00000120492.1, ENSDART00000134816.2
    Conserved Domains (2) summary
    cd06174
    Location:66 → 432
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 466
    Sugar_tr; Sugar (and other) transporter

  2. XM_005159425.5 → XP_005159482.1  solute carrier family 2, facilitated glucose transporter member 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5Y7
    Conserved Domains (2) summary
    cd06174
    Location:66 → 466
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 500
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version

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