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ric3b RIC3 acetylcholine receptor chaperone b [ Danio rerio (zebrafish) ]

Gene ID: 436654, updated on 4-Jan-2025

Summary

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Official Symbol
ric3bprovided by ZNC
Official Full Name
RIC3 acetylcholine receptor chaperone bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040323-1
See related
AllianceGenome:ZFIN:ZDB-GENE-040323-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ric3; zgc:92489
Summary
Predicted to enable acetylcholine receptor activity. Predicted to be involved in cholinergic synaptic transmission and protein localization to cell surface. Predicted to act upstream of or within chemical postsynaptic transmission. Predicted to be located in plasma membrane. Predicted to be active in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Is expressed in basal plate midbrain region and tegmentum. Orthologous to human RIC3 (RIC3 acetylcholine receptor chaperone). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See ric3b in Genome Data Viewer
Location:
chromosome: 25
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (37480169..37483811)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (36878612..36880521)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene Fanconi anemia group A protein Neighboring gene ribosomal protein L27a Neighboring gene zinc finger protein 276 Neighboring gene zinc finger C3H1 domain-containing protein Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene anoctamin-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. Halevi S, et al. J Biol Chem, 2003 Sep 5. PMID 12821669
  2. Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum. Theisen U, et al. PLoS Biol, 2018 Jan. PMID 29300740, Free PMC Article
  3. Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Ding X, et al. Environ Pollut, 2020 Dec. PMID 32841905
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acetylcholine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic transmission, cholinergic ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
protein RIC-3b
Names
resistance to inhibitors of cholinesterase 3 homolog b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002381.1 → NP_001002381.1  protein RIC-3b precursor

    See identical proteins and their annotated locations for NP_001002381.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076034
    UniProtKB/TrEMBL
    Q6DHE0
    Conserved Domains (1) summary
    pfam15361
    Location:24 → 157
    RIC3; Resistance to inhibitors of cholinesterase homologue 3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    37480169..37483811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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