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trmt61a tRNA methyltransferase 61A [ Danio rerio (zebrafish) ]

Gene ID: 436593, updated on 4-Jan-2025

Summary

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Official Symbol
trmt61aprovided by ZNC
Official Full Name
tRNA methyltransferase 61Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-5
See related
Ensembl:ENSDARG00000008480 AllianceGenome:ZFIN:ZDB-GENE-040718-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86657
Summary
Predicted to enable tRNA (adenine(58)-N1)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including eye; lens placode; midbrain; optic vesicle; and solid lens vesicle. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See trmt61a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15702069..15726304)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15570966..15595312)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882994 Neighboring gene MAP/microtubule affinity-regulating kinase 3a Neighboring gene creatine kinase, brain a Neighboring gene BCL2 associated athanogene 5 Neighboring gene cytochrome c oxidase assembly factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names
tRNA methyltransferase 61 homolog A
NP_001002321.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002321.1 → NP_001002321.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_001002321.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075759
    UniProtKB/TrEMBL
    A0A8M1N0C5, Q6DI31
    Related
    ENSDARP00000018195.7, ENSDART00000003517.9
    Conserved Domains (2) summary
    COG2519
    Location:9 → 299
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam08704
    Location:64 → 298
    GCD14; tRNA methyltransferase complex GCD14 subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    15702069..15726304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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