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zfh1 - Zn finger homeodomain 1

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including axon development; garland nephrocyte differentiation; and hemocyte development. Located in nucleus. Is expressed in several structures, including glial cell; larval neurons; somatic precursor cell; synaptic neuropil domain; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Hirschsprung's disease; Mowat-Wilson syndrome; and posterior polymorphous corneal dystrophy 3. Orthologous to several human genes including ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa