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CG12069 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43643, updated on 9-Dec-2024

Summary

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Official Symbol
CG12069provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039796
Locus tag
Dmel_CG12069
See related
AllianceGenome:FB:FBgn0039796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12069; Pka-like
Summary
Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in signal transduction. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12069 in Genome Data Viewer
Location:
100A2-100A2; 3-101 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30693572..30695498, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26519294..26521220, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45191 Neighboring gene Serpin 100A Neighboring gene long non-coding RNA:CR46115 Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. Cingolani P, et al. Front Genet, 2012. PMID 22435069, Free PMC Article
  2. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
  3. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
  4. Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Ugrankar R, et al. Nat Commun, 2015 May 21. PMID 25994086, Free PMC Article
  5. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Sonoshita M, et al. Nat Chem Biol, 2018 Mar. PMID 29355849, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12069-PA
CG12069-PC
PKA-like
NP_651819.1
NP_733396.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30693572..30695498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143562.2 → NP_651819.1  uncharacterized protein Dmel_CG12069, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VA47
    Related
    FBpp0085090
    Conserved Domains (2) summary
    PTZ00263
    Location:44 → 356
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cl21453
    Location:45 → 335
    PKc_like; Protein Kinases, catalytic domain

  2. NM_170517.3 → NP_733396.3  uncharacterized protein Dmel_CG12069, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733396.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VA47
    Conserved Domains (2) summary
    PTZ00263
    Location:44 → 356
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cl21453
    Location:45 → 335
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VA47 Q9VA47

Gene LinkOut

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