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tmod tropomodulin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43633, updated on 4-Jan-2025

Summary

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Official Symbol
tmodprovided by FlyBase
Official Full Name
tropomodulinprovided by FlyBase
Primary source
FLYBASE:FBgn0082582
Locus tag
Dmel_CG1539
See related
AllianceGenome:FB:FBgn0082582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1309/10; CG11493; CG1539; CG15540; CT3919; CT41421; Dmel\CG1539; E42; l(3)00848; l(3)S130910; spdo; Tmod
Summary
Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization and myofibril assembly. Located in fusome. Is active in M band. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; endoderm anlage; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2G; megacystis-microcolon-intestinal hypoperistalsis syndrome; and nemaline myopathy 10. Orthologous to several human genes including TMOD1 (tropomodulin 1); TMOD2 (tropomodulin 2); and TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See tmod in Genome Data Viewer
Location:
99F7-99F8; 3-100 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30532607..30578905)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26358329..26404627)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene jdp Neighboring gene long non-coding RNA:CR45552 Neighboring gene long non-coding RNA:CR45553 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 6-related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thin filaments elongate from their pointed ends during myofibril assembly in Drosophila indirect flight muscle. Mardahl-Dumesnil M, et al. J Cell Biol, 2001 Dec 10. PMID 11739412, Free PMC Article
  2. Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners. Farkas D, et al. PLoS Genet, 2024 Jan. PMID 38198522, Free PMC Article
  3. Germline cyst formation and incomplete cytokinesis during Drosophila melanogaster oogenesis. Ong S, et al. Dev Biol, 2010 Jan 1. PMID 19850028
  4. The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly. Shwartz A, et al. Elife, 2016 Oct 12. PMID 27731794, Free PMC Article
  5. Apical Sarcomere-like Actomyosin Contracts Nonmuscle Drosophila Epithelial Cells. Coravos JS, et al. Dev Cell, 2016 Nov 7. PMID 27773487, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase neuralized is required for both Delta endocytosis and the internalization of Sanpodo
    Title: Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
  2. Results suggest a model in which Numb inhibits Notch signaling through the regulation of Sanpodo membrane localization.
    Title: Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 30533855-30533900 mobile_element_type = transposon:gypsy{}3516

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex HDA PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tropomodulin
Names
CG1539-PA
CG1539-PB
CG1539-PC
CG1539-PD
CG1539-PE
CG1539-PF
CG1539-PG
CG1539-PH
CG1539-PI
CG1539-PJ
CG1539-PK
CG1539-PL
CG1539-PM
CG1539-PN
CG1539-PO
CG1539-PP
CG1539-PQ
CG1539-PR
sanpodo
tmod-PA
tmod-PB
tmod-PC
tmod-PD
tmod-PE
tmod-PF
tmod-PG
tmod-PH
tmod-PI
tmod-PJ
tmod-PK
tmod-PL
tmod-PM
tmod-PN
tmod-PO
tmod-PP
tmod-PQ
tmod-PR
tropmodulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30532607..30578905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170305.3 → NP_001163776.1  tropomodulin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IDG5, Q9VA59
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_001260442.2 → NP_001247371.1  tropomodulin, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7R6, Q6IDG5
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. NM_001382033.1 → NP_001369033.1  tropomodulin, isoform R [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EEH6, Q6IDG5
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. NM_001104512.4 → NP_001097982.1  tropomodulin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRH3, Q6IDG5
    Conserved Domains (2) summary
    cd00116
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:91 → 233
    Tropomodulin; Tropomodulin

  5. NM_170504.4 → NP_733383.1  tropomodulin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733383.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IDG5, Q9VA59
    Related
    FBpp0085020
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  6. NM_001202391.2 → NP_001189320.1  tropomodulin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IDG5, Q9VA59
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  7. NM_170503.4 → NP_733382.1  tropomodulin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IDG5, Q9VA59
    Related
    FBpp0085021
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  8. NM_001260443.2 → NP_001247372.1  tropomodulin, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247372.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6N4
    Conserved Domains (2) summary
    cd00116
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:91 → 233
    Tropomodulin; Tropomodulin

  9. NM_170505.4 → NP_733384.1  tropomodulin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6IDG5, Q9VA59
    Related
    FBpp0085022
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  10. NM_001276183.1 → NP_001263112.1  tropomodulin, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHW6, Q6IDG5
    Conserved Domains (2) summary
    pfam03250
    Location:91 → 233
    Tropomodulin
    cl39015
    Location:285 → 421
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  11. NM_001276182.1 → NP_001263111.1  tropomodulin, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHF2, Q6IDG5
    Conserved Domains (2) summary
    cd00116
    Location:285 → 434
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:91 → 233
    Tropomodulin; Tropomodulin

  12. NM_001170304.3 → NP_001163775.1  tropomodulin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV00, E1JJ21
    Conserved Domains (2) summary
    cd00116
    Location:218 → 301
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:24 → 166
    Tropomodulin; Tropomodulin

  13. NM_170506.3 → NP_733385.1  tropomodulin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV00, Q9VA58
    Related
    FBpp0085023
    Conserved Domains (2) summary
    cd00116
    Location:255 → 338
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:61 → 203
    Tropomodulin; Tropomodulin

  14. NM_001260444.2 → NP_001247373.1  tropomodulin, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247373.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAH8, C8VV00
    Conserved Domains (2) summary
    cd00116
    Location:255 → 338
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:61 → 203
    Tropomodulin; Tropomodulin

  15. NM_001202390.1 → NP_001189319.1  tropomodulin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAH8, C8VV00
    Conserved Domains (2) summary
    cd00116
    Location:255 → 338
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:61 → 203
    Tropomodulin; Tropomodulin

  16. NM_001170306.2 → NP_001163777.1  tropomodulin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV00, Q9VA58
    Conserved Domains (2) summary
    cd00116
    Location:255 → 338
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:61 → 203
    Tropomodulin; Tropomodulin

  17. NM_057683.5 → NP_477031.1  tropomodulin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477031.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV00, O46231, Q9VA57
    Related
    FBpp0085024
    Conserved Domains (2) summary
    cd00116
    Location:213 → 296
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:19 → 161
    Tropomodulin; Tropomodulin

  18. NM_057684.4 → NP_477032.1  tropomodulin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV00, Q9VA56
    Related
    FBpp0085025
    Conserved Domains (2) summary
    pfam03250
    Location:55 → 197
    Tropomodulin
    cl39015
    Location:249 → 332
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6N4 A0A0B4K6N4
A0A0B4K7R6 A0A0B4K7R6
A0A0B4KHF2 A0A0B4KHF2
A0A0B4KHW6 A0A0B4KHW6
A0A6H2EEH6 A0A6H2EEH6
A8JRH3 A8JRH3
C7LAH8 C7LAH8
E1JJ21 E1JJ21
O46231 O46231
Q9VA56 Q9VA56
Q9VA58 Q9VA58
Q9VA59 Q9VA59

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