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tbx-43 T-box domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 4363053, updated on 2-Nov-2024

Summary

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Official Symbol
tbx-43
Official Full Name
T-box domain-containing protein
Primary source
WormBase:WBGene00044798
Locus tag
CELE_Y46E12A.4
See related
AllianceGenome:WB:WBGene00044798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and primary immunodeficiency disease. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbx-43 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (1765407..1770093, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF72 domain-containing protein Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TLDc domain-containing protein Neighboring gene ncRNA Neighboring gene C4-dicarboxylate ABC transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Levin M, et al. Dev Cell, 2012 May 15. PMID 22560298
  2. Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments. Çelen İ, et al. Cells, 2023 Jan 10. PMID 36672205, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-box domain-containing protein
NP_001040883.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1765407..1770093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047418.4 → NP_001040883.1  T-box domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040883.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1T6W8
    Conserved Domains (2) summary
    pfam00907
    Location:5 → 183
    T-box; T-box
    pfam15323
    Location:170 → 221
    Ashwin; Developmental protein
Nucleotide Protein
Heading Accession and Version

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