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Jon99Fii Jonah 99Fii [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43621, updated on 4-Jan-2025

Summary

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Official Symbol
Jon99Fiiprovided by FlyBase
Official Full Name
Jonah 99Fiiprovided by FlyBase
Primary source
FLYBASE:FBgn0039777
Locus tag
Dmel_CG2229
See related
AllianceGenome:FB:FBgn0039777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2229; Dmel\CG2229; Jon99F; Jon99fii; Jon99FII; SP135
Summary
Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Jon99Fii in Genome Data Viewer
Location:
99F6-99F6; 3-100 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30487016..30487928, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26312738..26313650, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ceramidase Neighboring gene prolyl-4-hydroxylase-alpha EFB Neighboring gene sanpodo Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene Jonah 99Fi Neighboring gene prolyl-4-hydroxylase-alpha MP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Hang S, et al. Cell Host Microbe, 2014 Nov 12. PMID 25525791, Free PMC Article
  2. Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Meers MP, et al. Elife, 2017 Mar 27. PMID 28346137, Free PMC Article
  3. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
  4. Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast. Junell A, et al. Insect Biochem Mol Biol, 2007 Mar. PMID 17296495
  5. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
jonah 99Fii
Names
CG2229-PA
Jon99Fii-PA
jonah 99F
NP_651799.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30487016..30487928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143542.2 → NP_651799.1  jonah 99Fii [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYK8, Q9VA67
    Related
    FBpp0085052
    Conserved Domains (2) summary
    smart00020
    Location:37 → 259
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:38 → 262
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VA67 Q9VA67

Gene LinkOut

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