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PH4alphaEFB prolyl-4-hydroxylase-alpha EFB [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43620, updated on 9-Dec-2024

Summary

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Official Symbol
PH4alphaEFBprovided by FlyBase
Official Full Name
prolyl-4-hydroxylase-alpha EFBprovided by FlyBase
Primary source
FLYBASE:FBgn0039776
Locus tag
Dmel_CG31022
See related
AllianceGenome:FB:FBgn0039776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD05564; CG12088; CG1473; CG31022; Dmel\CG31022; PH4-aEFB; PH4alpha-EFB
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Located in endomembrane system. Is expressed in several structures, including adult brain cell body rind; adult head; dorsal epidermis primordium; embryonic dorsal epidermis; and follicle cell. Human ortholog(s) of this gene implicated in myopia. Orthologous to several human genes including P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See PH4alphaEFB in Genome Data Viewer
Location:
99F6-99F6; 3-100 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30466050..30485799)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26291772..26311521)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ceramidase Neighboring gene sanpodo Neighboring gene Jonah 99Fii Neighboring gene Jonah 99Fi

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila. Isabella AJ, et al. Dev Biol, 2015 Oct 15. PMID 26348027, Free PMC Article
  2. Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Wilmes AC, et al. Biol Open, 2018 Apr 23. PMID 29685999, Free PMC Article
  3. Variations in basement membrane mechanics are linked to epithelial morphogenesis. Chlasta J, et al. Development, 2017 Dec 1. PMID 29038305
  4. Ceramidase regulates synaptic vesicle exocytosis and trafficking. Rohrbough J, et al. J Neurosci, 2004 Sep 8. PMID 15356190, Free PMC Article
  5. Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis. Van De Bor V, et al. Cell Rep, 2015 Oct 20. PMID 26456819

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolyl-4-hydroxylase-alpha EFB
Names
CG31022-PA
PH4alphaEFB-PA
propyl-4-hydroxylase-alpha EFB
NP_733371.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30466050..30485799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170492.2 → NP_733371.1  prolyl-4-hydroxylase-alpha EFB [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960D8, Q9VA69
    Related
    FBpp0085012
    Conserved Domains (2) summary
    smart00702
    Location:356 → 529
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:28 → 159
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VA69 Q9VA69

Gene LinkOut

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