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MRC1 mannose receptor C-type 1 [ Homo sapiens (human) ]

Gene ID: 4360, updated on 27-Nov-2024

Summary

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Official Symbol
MRC1provided by HGNC
Official Full Name
mannose receptor C-type 1provided by HGNC
Primary source
HGNC:HGNC:7228
See related
Ensembl:ENSG00000260314 MIM:153618; AllianceGenome:HGNC:7228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
Summary
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Annotation information
Note: In the NCBI Build 37.2 reference assembly, MRC1 and MRC1L1 are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. Two of the clones on which MRC1L1 was based (AL928580, BX255924) will be removed from the reference assembly and only MRC1 will be present in the assembly. [13 Feb 2013]
Expression
Broad expression in lung (RPKM 50.7), spleen (RPKM 28.0) and 19 other tissues See more
Orthologs
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Genomic context

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See MRC1 in Genome Data Viewer
Location:
10p12.33
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17809348..17911164)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17828682..17930487)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18098337..18200093)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:17685753-17686402 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17713088-17713842 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:17715682-17716218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:17728822-17729322 Neighboring gene MPRA-validated peak889 silencer Neighboring gene signal transducing adaptor molecule Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17829359-17829976 Neighboring gene transmembrane protein 236 Neighboring gene uncharacterized LOC124902600 Neighboring gene microRNA 511 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:18270087-18271286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3111 Neighboring gene solute carrier family 39 member 12 Neighboring gene SLC39A12 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:18324740-18325329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:18325330-18325918 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:18355421-18356620 Neighboring gene MPRA-validated peak890 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr10:18424852-18425818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11486 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. Zhang J, et al. J Leukoc Biol, 2005 Sep. PMID 16000387
  2. Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum. Grover M, et al. Neurogastroenterol Motil, 2017 Jun. PMID 28066953, Free PMC Article
  3. The sdLDL Reduces MRC1 Expression Level and Secretion of Histamin e in Differentiated M2-macrophages from Patients with Coronary Artery Stenosis. Yarnazari A, et al. Cardiovasc Hematol Disord Drug Targets, 2017 Jul 4. PMID 28059035
  4. Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis. Izumi G, et al. Fertil Steril, 2017 Jan. PMID 27793384
  5. Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases. Wollenberg A, et al. J Invest Dermatol, 2002 Feb. PMID 11841552

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
    Title: Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
  2. Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
    Title: Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
  3. Soluble CD206 levels correlate with disease deterioration and predict prognosis of anti-MDA5 antibody-positive dermatomyositis related interstitial lung disease.
    Title: Soluble CD206 levels correlate with disease deterioration and predict prognosis of anti-MDA5 antibody-positive dermatomyositis related interstitial lung disease.
  4. CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis.
    Title: CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis.
  5. CD206[+]CD68[+] mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis.
    Title: CD206(+)CD68(+) mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis.
  6. Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters.
    Title: Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters.
  7. The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease.
    Title: The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease.
  8. CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma.
    Title: CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma.
  9. Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis.
    Title: Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis.
  10. The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer.
    Title: The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of mannose receptor, C type 1 (MRC1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells PubMed
env Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay PubMed
env Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells PubMed
env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
Nef nef HIV-1 Nef downregulates mannose receptor (MR) on the surface of macrophages and dendritic cells (DC); both NTLY and SDXXXL motifs in the cytoplasmic tail of MR are critical for the cell surface reduction of MR PubMed
Tat tat HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters PubMed
tat HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC181940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-mannose binding IEA
Inferred from Electronic Annotation
more info
  
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
macrophage mannose receptor 1
Names
C-type lectin domain family 13 member D
human mannose receptor
macrophage mannose receptor 1-like protein 1
mannose receptor, C type 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047011.1 RefSeqGene

    Range
    5006..106822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002438.4 → NP_002429.1  macrophage mannose receptor 1 precursor

    See identical proteins and their annotated locations for NP_002429.1

    Status: REVIEWED

    Source sequence(s)
    AC069023, AL139238, AV659122, DC296466, J05550
    Consensus CDS
    CCDS7123.2
    UniProtKB/Swiss-Prot
    A5PKW3, P22897, Q5VSJ2, Q5VSK2
    UniProtKB/TrEMBL
    Q0Z8D6
    Related
    ENSP00000455897.1, ENST00000569591.3
    Conserved Domains (5) summary
    smart00059
    Location:161 → 209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:659 → 779
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:362 → 487
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:27 → 142
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:34 → 141
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    17809348..17911164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    17828682..17930487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009567.1: Suppressed sequence

    Description
    NM_001009567.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22897.1 GenPept UniProtKB/Swiss-Prot:P22897

Gene LinkOut

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