AdoR Adenosine receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AdoRprovided by FlyBase
Official Full Name: Adenosine receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0039747
Locus tag: Dmel_CG9753
See related: AllianceGenome:FB:FBgn0039747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: adoR; anon-WO0170980.109; anon-WO0170980.110; CG9753; dAdoR; dADOR; DmAdoR; Dmel\CG9753
Summary: Enables G protein-coupled adenosine receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; associative learning; and negative regulation of calcium ion import. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval optic lobe; embryonic/larval salivary gland; imaginal disc; and larval ring gland. Human ortholog(s) of this gene implicated in asthma. Orthologous to several human genes including ADORA1 (adenosine A1 receptor); ADORA2A (adenosine A2a receptor); and ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30134856..30149606, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25960578..25975328, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled adenosine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled adenosine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of carbohydrate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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