Tace - tace
Enables metalloendopeptidase activity. Involved in several processes, including cell surface receptor signaling pathway; commissural neuron axon guidance; and membrane protein ectodomain proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Dec 2024]
NCBI Orthologs
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Protein alignment
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