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TkR99D Tachykinin-like receptor at 99D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43551, updated on 9-Dec-2024

Summary

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Official Symbol
TkR99Dprovided by FlyBase
Official Full Name
Tachykinin-like receptor at 99Dprovided by FlyBase
Primary source
FLYBASE:FBgn0004622
Locus tag
Dmel_CG7887
See related
AllianceGenome:FB:FBgn0004622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0131005.11; anon-WO0131005.9; CG7887; Dmel\CG7887; DmTRPR; dtkr; Dtkr; DTKR; l(3)s2222; Tak-r; TAKR; Takr99D; TakR99D; TAKR99D; Tk-R 99D; Tkr99D; TKR99D; TLR2_DROME
Summary
Enables tachykinin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception of smell; and positive regulation of sensory perception of pain. Located in plasma membrane. Is expressed in several structures, including ganglia; gut section; protocerebrum; specialized Malpighian tubule cell; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in asthma; developmental disorder of mental health; exercise-induced bronchoconstriction; and hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to several human genes including TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See TkR99D in Genome Data Viewer
Location:
99C8-99D1; 3-100 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29950796..29969447, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25776518..25795169, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit alpha Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13B Neighboring gene uncharacterized protein Neighboring gene Acid phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides. Li XJ, et al. EMBO J, 1991 Nov. PMID 1717263, Free PMC Article
  2. Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster. Li XJ, et al. J Biol Chem, 1992 Jan 5. PMID 1370455
  3. Local peptidergic signaling in the antennal lobe shapes olfactory behavior. Winther AM, et al. Fly (Austin), 2010 Apr-Jun. PMID 20224300
  4. Tachykinin-related peptides and their receptors in invertebrates: a current view. Van Loy T, et al. Peptides, 2010 Mar. PMID 19781585
  5. Functional comparison of two evolutionary conserved insect neurokinin-like receptors. Poels J, et al. Peptides, 2007 Jan. PMID 17141920

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neuropeptide receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tachykinin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tachykinin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables tachykinin receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tachykinin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tachykinin-like receptor at 99D
Names
CG7887-PA
CG7887-PB
CG7887-PC
DTK receptor
TkR99D-PA
TkR99D-PB
TkR99D-PC
drosophila tachykinin receptor
tachykinin receptor
tachykinin-like receptor at 99D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29950796..29969447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170301.1 → NP_001163772.1  Tachykinin-like receptor at 99D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ17
    Conserved Domains (2) summary
    pfam00001
    Location:118 → 381
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:113 → 396
    7tm_4; Olfactory receptor

  2. NM_079832.3 → NP_524556.2  Tachykinin-like receptor at 99D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524556.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30975, Q8T0S8, Q9VAD2
    Related
    FBpp0084873
    Conserved Domains (2) summary
    pfam00001
    Location:118 → 381
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:113 → 396
    7tm_4; Olfactory receptor

  3. NM_001276163.1 → NP_001263092.1  Tachykinin-like receptor at 99D, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263092.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHV8
    Conserved Domains (2) summary
    pfam00001
    Location:118 → 381
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:113 → 396
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHV8 A0A0B4KHV8
E1JJ17 E1JJ17
P30975.2 P30975

Gene LinkOut

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