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Vps13B Vacuolar protein sorting 13B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43550, updated on 9-Dec-2024

Summary

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Official Symbol
Vps13Bprovided by FlyBase
Official Full Name
Vacuolar protein sorting 13Bprovided by FlyBase
Primary source
FLYBASE:FBgn0039727
Locus tag
Dmel_CG15523
See related
AllianceGenome:FB:FBgn0039727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15523; Dmel\CG15523
Summary
Predicted to be involved in protein targeting to vacuole. Predicted to be extrinsic component of membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Cohen syndrome. Orthologous to human VPS13B (vacuolar protein sorting 13 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Vps13B in Genome Data Viewer
Location:
99C7-99C7; 3-99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29935978..29948207)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25761700..25773929)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit alpha Neighboring gene Component of oligomeric golgi complex 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tachykinin-like receptor at 99D Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Anding AL, et al. Curr Biol, 2018 Jan 22. PMID 29307555, Free PMC Article
  2. Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster. Gradilla AC, et al. Genetics, 2011 Nov. PMID 21900267, Free PMC Article
  3. Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. Esslinger SM, et al. RNA Biol, 2013 Jun. PMID 23669073, Free PMC Article
  4. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
  5. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein targeting to vacuole ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
vacuolar protein sorting 13B
Names
CG15523-PA
CG15523-PB
Vps13B-PA
Vps13B-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29935978..29948207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143496.4 → NP_651753.2  vacuolar protein sorting 13B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651753.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAD3
    Conserved Domains (3) summary
    pfam09333
    Location:3473 → 3546
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:5 → 117
    Chorein_N; N-terminal region of Chorein or VPS13
    pfam16909
    Location:3319 → 3468
    VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal

  2. NM_206587.2 → NP_996310.2  vacuolar protein sorting 13B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996310.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1RKY3
    Conserved Domains (2) summary
    pfam12624
    Location:5 → 117
    Chorein_N; N-terminal region of Chorein or VPS13
    pfam16908
    Location:135 → 203
    VPS13; Vacuolar sorting-associated protein 13, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1RKY3 Q1RKY3
Q9VAD3 Q9VAD3

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