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Rnb R and B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43513, updated on 9-Dec-2024

Summary

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Official Symbol
Rnbprovided by FlyBase
Official Full Name
R and Bprovided by FlyBase
Primary source
FLYBASE:FBgn0039696
Locus tag
Dmel_CG7837
See related
AllianceGenome:FB:FBgn0039696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7837; Dmel\CG7837
Summary
Involved in regulation of circadian rhythm. Located in cytosol. Is expressed in adult brain cell body rind. Human ortholog(s) of this gene implicated in ACTH-independent macronodular adrenal hyperplasia 2. Orthologous to human ARMC5 (armadillo repeat containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rnb in Genome Data Viewer
Location:
99C1-99C1; 3-99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29795697..29799354, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25621419..25625076, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene kayak Neighboring gene long non-coding RNA:CR46110 Neighboring gene fos intronic gene Neighboring gene shroud Neighboring gene Death related ICE-like caspase Neighboring gene Electron transfer flavoprotein beta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Screening of UNF Targets Identifies Rnb, a Novel Regulator of Drosophila Circadian Rhythms. Kozlov A, et al. J Neurosci, 2017 Jul 12. PMID 28592698, Free PMC Article
  2. Wnt pathway activation increases hypoxia tolerance during development. Gersten M, et al. PLoS One, 2014. PMID 25093834, Free PMC Article
  3. DRONC coordinates cell death and compensatory proliferation. Kondo S, et al. Mol Cell Biol, 2006 Oct. PMID 16980627, Free PMC Article
  4. The tobacco phosphatidylethanolamine-binding protein NtFT4 increases the lifespan of Drosophila melanogaster by interacting with the proteostasis network. Känel P, et al. Aging (Albany NY), 2022 Apr 8. PMID 35396341, Free PMC Article
  5. Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Lye CM, et al. Development, 2014 Oct. PMID 25294944, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of circadian rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
R and B
Names
CG7837-PA
Rnb-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29795697..29799354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143469.2 → NP_651726.1  R and B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAH2
    Related
    FBpp0084903
    Conserved Domains (3) summary
    smart00225
    Location:801 → 904
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00020
    Location:44 → 147
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:49 → 78
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAH2 Q9VAH2

Gene LinkOut

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