Bub3 Bub3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bub3provided by FlyBase
Official Full Name: Bub3provided by FlyBase
Primary source: FLYBASE:FBgn0025457
Locus tag: Dmel_CG7581
See related: AllianceGenome:FB:FBgn0025457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bub3; BUB3; CG7581; dBUB3; Dmbub3; Dmel\CG7581
Summary: Predicted to enable ubiquitin binding activity. Involved in mitotic spindle assembly checkpoint signaling. Located in kinetochore and nucleoplasm. Is expressed in several structures, including CNS glial cell; adult head; anterior endoderm; embryonic/larval midgut primordium; and ganglia. Used to study cancer. Orthologous to human BUB3 (BUB3 mitotic checkpoint protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29674007..29675421, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25499729..25501143, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bub1 and Bub3 regulate metabolic adaptation via macrolipophagy in Drosophila.
Title: Bub1 and Bub3 regulate metabolic adaptation via macrolipophagy in Drosophila.
The Bub3-BubR1 complex on broken DNA inhibits the APC/C locally via the sequestration of Cdc20.
Title: Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes.
Bub3 has a nonkinetochore-dependent function that is consistent with its role as a tumor suppressor.
Title: A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition.
Bub3 is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis.
Title: The Drosophila Bub3 protein is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of bub1-bub3 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of mitotic checkpoint complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

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