ppk30 pickpocket 30 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ppk30provided by FlyBase
Official Full Name: pickpocket 30provided by FlyBase
Primary source: FLYBASE:FBgn0039677
Locus tag: Dmel_CG18110
See related: AllianceGenome:FB:FBgn0039677
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18110; Dmel\CG18110; Ppk30
Summary: Enables mechanosensitive monoatomic cation channel activity and pH-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception of pain and regulation of terminal button organization. Part of sodium channel complex. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29669149..29671478)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25494871..25497200)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Ppk30 has a functional role in mechanosensation in class IV neurons.
Title: Impairment of proprioceptive movement and mechanical nociception in Drosophila melanogaster larvae lacking Ppk30, a Drosophila member of the Degenerin/Epithelial Sodium Channel family.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables mechanosensitive monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables pH-gated monoatomic ion channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium channel complex	IPI Inferred from Physical Interaction more info	PubMed