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FipoQ F-box involved in polyQ pathogenesis [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43475, updated on 9-Dec-2024

Summary

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Official Symbol
FipoQprovided by FlyBase
Official Full Name
F-box involved in polyQ pathogenesisprovided by FlyBase
Primary source
FLYBASE:FBgn0039667
Locus tag
Dmel_CG2010
See related
AllianceGenome:FB:FBgn0039667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2010; Dmel\CG2010; FBXL3
Summary
Involved in positive regulation of protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adult head; dorsal pharyngeal muscle cell; larval muscle system; larval somatic muscle cell; and larval visceral muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See FipoQ in Genome Data Viewer
Location:
99B1-99B1; 3-99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29494782..29498923)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25320504..25324645)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene diedel Neighboring gene TRC8 ring finger protein Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
  2. FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. Chen ZS, et al. J Neurochem, 2019 Jun. PMID 30685895
  3. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
  4. F-box proteins: the key to protein degradation. Ho MS, et al. J Biomed Sci, 2006 Mar. PMID 16463014
  5. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Dui W, et al. J Genet Genomics, 2012 Aug 20. PMID 22884096

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
F-box involved in polyQ pathogenesis
Names
CG2010-PA
CG2010-PB
CG2010-PC
FipoQ-PA
FipoQ-PB
FipoQ-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29494782..29498923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143439.3 → NP_651696.1  F-box involved in polyQ pathogenesis, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGU5, Q8T0K1
    Related
    FBpp0084795
    Conserved Domains (2) summary
    sd00034
    Location:215 → 240
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:30 → 76
    F-box-like; F-box-like

  2. NM_001276140.1 → NP_001263069.1  F-box involved in polyQ pathogenesis, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGU5, Q8T0K1
    Conserved Domains (2) summary
    sd00034
    Location:215 → 240
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:30 → 76
    F-box-like; F-box-like

  3. NM_170412.2 → NP_733291.1  F-box involved in polyQ pathogenesis, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733291.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGU5, Q9VAK7
    Related
    FBpp0084796
    Conserved Domains (2) summary
    sd00034
    Location:219 → 244
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:34 → 80
    F-box-like; F-box-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGU5 Q8IGU5
Q8T0K1 Q8T0K1
Q9VAK7 Q9VAK7

Gene LinkOut

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