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Diedel diedel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43474, updated on 4-Jan-2025

Summary

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Official Symbol
Diedelprovided by FlyBase
Official Full Name
diedelprovided by FlyBase
Primary source
FLYBASE:FBgn0039666
Locus tag
Dmel_CG11501
See related
AllianceGenome:FB:FBgn0039666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH38110; CG11501; die; Die; diedel; Dmel\CG11501
Summary
Enables cytokine activity. Involved in defense response to virus and response to bacterium. Located in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Diedel in Genome Data Viewer
Location:
99B1-99B1; 3-99 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29493852..29494267)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25319574..25319989)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Spase 12-subunit Neighboring gene uncharacterized protein Neighboring gene F-box involved in polyQ pathogenesis Neighboring gene TRC8 ring finger protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity. Lamiable O, et al. Fly (Austin), 2016 Oct. PMID 27314646, Free PMC Article
  2. cGAS-like receptor-mediated immunity: the insect perspective. Cai H, et al. Curr Opin Immunol, 2022 Feb. PMID 35149240
  3. Integrin-ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium. Mlih M, et al. PLoS Biol, 2022 May. PMID 35522719, Free PMC Article
  4. Pleiotropy of the Drosophila JAK pathway cytokine Unpaired 3 in development and aging. Wang L, et al. Dev Biol, 2014 Nov 15. PMID 25245869
  5. Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster. Srinivasan N, et al. Elife, 2016 Nov 22. PMID 27871362, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diedel is an inhibitor of apoptosis and can act as a systemic rheostat to modulate cell death during aging.
    Title: A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis.
  2. Study established that WntD and Die are 2 cytokines that regulate independently the expression of edin during infection by an intracellular bacteria and a virus, respectively.
    Title: WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity.
  3. die mutant flies have shortened lifespan and succumb more rapidly than controls when infected with Sindbis virus.
    Title: Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.
  4. Diedel, a marker of the Drosophila antimicrobial/antiviral response, is a member of a small family of proteins present in drosophilids, aphids and DNA viruses infecting lepidopterans
    Title: Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytokine activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
diedel
Names
CG11501-PA
Diedel-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29493852..29494267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143438.3 → NP_651695.1  diedel [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651695.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAK8
    UniProtKB/TrEMBL
    A0A1B2AJC0
    Related
    FBpp0084794
    Conserved Domains (1) summary
    pfam13164
    Location:27 → 100
    DUF4002; Protein of unknown function (DUF4002)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAK8.1 Q9VAK8

Gene LinkOut

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