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Ptp99A Protein tyrosine phosphatase 99A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43469, updated on 4-Jan-2025

Summary

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Official Symbol
Ptp99Aprovided by FlyBase
Official Full Name
Protein tyrosine phosphatase 99Aprovided by FlyBase
Primary source
FLYBASE:FBgn0004369
Locus tag
Dmel_CG11516
See related
AllianceGenome:FB:FBgn0004369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11515; CG11516; CG11517; CG2005; CT6383; Dmel\CG11516; dptp99A; Dptp99A; DPTP99A; DPTP[[99A]]; ptp99A; PTP99A; R-PTP 99A
Summary
Enables protein tyrosine phosphatase activity. Involved in defasciculation of motor neuron axon and motor neuron axon guidance. Located in axon. Is expressed in several structures, including adult fat body; adult head; ganglia; larval CNS neuron; and neuron projection bundle. Orthologous to several human genes including PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ptp99A in Genome Data Viewer
Location:
99A7-99B1; 3-98 cM
Exon count:
22
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29377646..29487131)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25203368..25312853)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45547 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44022 Neighboring gene uncharacterized protein Neighboring gene Spase 12-subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Hariharan IK, et al. Proc Natl Acad Sci U S A, 1991 Dec 15. PMID 1662390, Free PMC Article
  2. Inter-domain interactions influence the stability and catalytic activity of the bi-domain protein tyrosine phosphatase PTP99A. Madan LL, et al. Biochim Biophys Acta, 2012 Aug. PMID 22595398
  3. Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Yang XH, et al. Cell, 1991 Nov 15. PMID 1657401
  4. Axon guidance: motor-way madness. Stoker AW. Curr Biol, 1996 Jul 1. PMID 8835859
  5. Tyrosine phosphorylation and axon guidance: of mice and flies. Desai CJ, et al. Curr Opin Neurobiol, 1997 Feb. PMID 9039791

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. During embryonic development of the mushroom body, Ptp99A is expressed within an expanded core region including somewhat older axons.
    Title: Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 29406674-29407871 mobile_element_type = transposon:jockey{}1451

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane receptor protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonal defasciculation TAS
Traceable Author Statement
more info
 PubMed 
involved_in defasciculation of motor neuron axon IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
protein tyrosine phosphatase 99A
Names
CG11516-PA
CG11516-PB
CG11516-PC
CG11516-PF
CG11516-PG
Ptp99A-PA
Ptp99A-PB
Ptp99A-PC
Ptp99A-PF
Ptp99A-PG
NP_001189309.1
NP_476816.1
NP_651691.4
NP_733288.1
NP_996302.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29377646..29487131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143434.5 → NP_651691.4  protein tyrosine phosphatase 99A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651691.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAL5
    Conserved Domains (4) summary
    smart00194
    Location:646 → 911
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:676 → 911
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:342 → 437
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:249 → 331
    fn3; Fibronectin type III domain

  2. NM_206579.3 → NP_996302.1  protein tyrosine phosphatase 99A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996302.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35832, Q59DT5, Q7KRW3, Q8IMK9, Q9VAL3
    Conserved Domains (3) summary
    smart00194
    Location:490 → 755
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:520 → 755
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:171 → 281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_170409.3 → NP_733288.1  protein tyrosine phosphatase 99A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733288.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35832, Q59DT5, Q7KRW3, Q8IMK9, Q9VAL3
    Conserved Domains (3) summary
    smart00194
    Location:475 → 740
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:505 → 740
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:171 → 266
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. NM_057468.3 → NP_476816.1  protein tyrosine phosphatase 99A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476816.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35832, Q59DT5, Q7KRW3, Q8IMK9, Q9VAL3
    Conserved Domains (3) summary
    smart00194
    Location:475 → 740
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:505 → 740
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:171 → 266
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. NM_001202380.2 → NP_001189309.1  protein tyrosine phosphatase 99A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189309.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDF4
    Conserved Domains (2) summary
    smart00194
    Location:100 → 365
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:130 → 365
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JDF4 A0A0B4JDF4
P35832.2 P35832
Q9VAL5 Q9VAL5

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