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Mesh1 Metazoan SpoT homolog-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43456, updated on 9-Dec-2024

Summary

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Official Symbol
Mesh1provided by FlyBase
Official Full Name
Metazoan SpoT homolog-1provided by FlyBase
Primary source
FLYBASE:FBgn0039650
Locus tag
Dmel_CG11900
See related
AllianceGenome:FB:FBgn0039650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11900; Dmel\CG11900; Q9VAM9
Summary
Enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Involved in guanosine tetraphosphate catabolic process and response to starvation. Is expressed in organism. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mesh1 in Genome Data Viewer
Location:
99A1-99A1; 3-98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29201756..29202525, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25027478..25028247, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene julius seizure Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome c1-like Neighboring gene long non-coding RNA::CR31044 Neighboring gene mir-279 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The regulation of ferroptosis by MESH1 through the activation of the integrative stress response. Lin CC, et al. Cell Death Dis, 2021 Jul 22. PMID 34294679, Free PMC Article
  2. Estimates of Rel(Seq), Mesh1, and SAH(Mex) Hydrolysis of (p)ppGpp and (p)ppApp by Thin Layer Chromatography and NADP/NADH Coupled Assays. Potrykus K, et al. Front Microbiol, 2020. PMID 33193211, Free PMC Article
  3. ppGpp functions as an alarmone in metazoa. Ito D, et al. Commun Biol, 2020 Nov 13. PMID 33188280, Free PMC Article
  4. Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli. Zhu M, et al. Nucleic Acids Res, 2019 May 21. PMID 30916318, Free PMC Article
  5. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Sun D, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818390

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The regulation of ferroptosis by MESH1 through the activation of the integrative stress response.
    Title: The regulation of ferroptosis by MESH1 through the activation of the integrative stress response.
  2. we highlight the Mesh1 (p)ppGpp hydrolase from Drosophila melanogaster as a powerful genetic tool for interrogating bacterial (p)ppGpp physiology.
    Title: Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli.
  3. Mesh1, encoded by Q9VAM9, has an active site for ppGpp hydrolysis & a conserved His-Asp-box motif for Mn(2+) binding. Deletion slows growth, impairs starvation resistance, downregulates DNA/protein synthesis genes & upregulates stress genes.
    Title: A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in guanosine tetraphosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
metazoan SpoT homolog-1
Names
CG11900-PA
Mesh1-PA
NP_651682.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29201756..29202525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143425.2 → NP_651682.1  metazoan SpoT homolog-1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651682.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAM9
    Related
    FBpp0084776
    Conserved Domains (1) summary
    COG0317
    Location:13 → 147
    SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAM9.1 Q9VAM9

Gene LinkOut

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