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Pglym78 Phosphoglyceromutase 78 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43447, updated on 9-Dec-2024

Summary

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Official Symbol
Pglym78provided by FlyBase
Official Full Name
Phosphoglyceromutase 78provided by FlyBase
Primary source
FLYBASE:FBgn0014869
Locus tag
Dmel_CG1721
See related
AllianceGenome:FB:FBgn0014869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1721; Dmel\CG1721; PGAM; Pglym; PGLYM; pglym78
Summary
Predicted to enable 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity and bisphosphoglycerate mutase activity. Involved in canonical glycolysis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; germline cell; larval muscle system; and muscle cell. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM1 (phosphoglycerate mutase 1); PGAM2 (phosphoglycerate mutase 2); and PGAM4 (phosphoglycerate mutase family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pglym78 in Genome Data Viewer
Location:
98F12-98F13; 3-97 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29148248..29149901)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24973970..24975623)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Suppressor of ER stress-induced death Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene Stem-loop binding protein Neighboring gene Regulatory particle non-ATPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure, expression and duplication of genes which encode phosphoglyceromutase of Drosophila melanogaster. Currie PD, et al. Genetics, 1994 Oct. PMID 7828819, Free PMC Article
  2. Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression. Sullivan E, et al. Genes Dev, 2001 Jan 15. PMID 11157774, Free PMC Article
  3. Analysis of glycolytic enzyme co-localization in Drosophila flight muscle. Sullivan DT, et al. J Exp Biol, 2003 Jun. PMID 12756285
  4. Ecdysone and 20-hydroxyecdysone are not required to activate glycolytic gene expression in Drosophila melanogaster embryos. Tennessen JM. MicroPubl Biol, 2021. PMID 34870111, Free PMC Article
  5. The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Tennessen JM, et al. Cell Metab, 2011 Feb 2. PMID 21284981, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables bisphosphoglycerate mutase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phosphoglyceromutase 78
Names
CG1721-PA
CG1721-PB
CG1721-PC
Pglym78-PA
Pglym78-PB
Pglym78-PC
phosphoglycerate mutase
phosphoglycerol mutase
phosphoglyceromutase
phosphogylcerate mutase 78
NP_001034075.1
NP_001034076.1
NP_524546.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29148248..29149901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079822.3 → NP_524546.2  phosphoglyceromutase 78, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524546.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5XD87, A5XD88, Q961P1, Q9VAN7
    Related
    FBpp0084753
    Conserved Domains (1) summary
    cl11399
    Location:5 → 255
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. NM_001038986.3 → NP_001034075.1  phosphoglyceromutase 78, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5XD87, A5XD88, Q961P1, Q9VAN7
    Conserved Domains (1) summary
    cl11399
    Location:5 → 255
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  3. NM_001038987.2 → NP_001034076.1  phosphoglyceromutase 78, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5XD87, A5XD88, Q961P1, Q9VAN7
    Conserved Domains (1) summary
    cl11399
    Location:5 → 255
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24450 Q24450
Q9GU73 Q9GU73
Q9VAN7 Q9VAN7

Gene LinkOut

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