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Gp93 Glycoprotein 93 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43354, updated on 9-Dec-2024

Summary

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Official Symbol
Gp93provided by FlyBase
Official Full Name
Glycoprotein 93provided by FlyBase
Primary source
FLYBASE:FBgn0039562
Locus tag
Dmel_CG5520
See related
AllianceGenome:FB:FBgn0039562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5520; CT17486; dGRP94; dHSP90; Dmel\CG5520; gp93; GP93; Hsp90; HSP90; Hsp90aa1; HSP90B1; p93; Q9VAY2
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Involved in endodermal digestive tract morphogenesis and midgut development. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic proventriculus; embryonic ventral epidermis; and epithelium. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gp93 in Genome Data Viewer
Location:
98B6-98B6; 3-94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27948711..27952151)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23774433..23777873)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Biorientation Defective 1 Neighboring gene mitoferrin Neighboring gene uncharacterized protein Neighboring gene Neprilysin 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90). Sawarkar R. Methods Mol Biol, 2023. PMID 37540426
  2. Development of a Grp94 inhibitor. Duerfeldt AS, et al. J Am Chem Soc, 2012 Jun 13. PMID 22642269, Free PMC Article
  3. Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. Morales C, et al. J Immunol, 2009 Oct 15. PMID 19786553, Free PMC Article
  4. Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. Pantzartzi CN, et al. PLoS One, 2013. PMID 24066039, Free PMC Article
  5. Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms. Chen B, et al. BMC Genomics, 2006 Jun 17. PMID 16780600, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
    Title: Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
  2. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization.
    Title: Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization.
  3. analysis of the role of Drosophila CNPYa and CNPYb in gp93 biology
    Title: Drosophila canopy b is a cochaperone of glycoprotein 93.
  4. an essential role for Gp93 in the functional expression of secretory/integral membrane protein-encoding lab protein target genes and/or integral membrane protein(s) that interact with the spectrin cytoskeleton to confer epithelial membrane specialization
    Title: Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.
  5. gp93 is the Drosophila ortholog of gp96, the chaperone function of the two molecules is conserved.
    Title: Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endodermal digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycoprotein 93
Names
CG5520-PA
Gp93-PA
glycoprotein93
heat shock protein 90

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27948711..27952151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143344.3 → NP_651601.1  glycoprotein 93 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAY2
    Related
    FBpp0084623
    Conserved Domains (3) summary
    PRK05218
    Location:74 → 745
    PRK05218; heat shock protein 90; Provisional
    cd00075
    Location:97 → 216
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam00183
    Location:257 → 748
    HSP90; Hsp90 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAY2 Q9VAY2

Gene LinkOut

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