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BOD1 Biorientation Defective 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43352, updated on 4-Jan-2025

Summary

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Official Symbol
BOD1provided by FlyBase
Official Full Name
Biorientation Defective 1provided by FlyBase
Primary source
FLYBASE:FBgn0039560
Locus tag
Dmel_CG5514
See related
AllianceGenome:FB:FBgn0039560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bod1; CG5514; Dmel\CG5514
Summary
Involved in nonassociative learning and synaptic assembly at neuromuscular junction. Predicted to be part of Set1C/COMPASS complex. Is expressed in embryonic/larval salivary gland and organism. Used to study intellectual disability. Orthologous to several human genes including BOD1 (biorientation of chromosomes in cell division 1) and BOD1L2 (biorientation of chromosomes in cell division 1 like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See BOD1 in Genome Data Viewer
Location:
98B6-98B6; 3-94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27938245..27942778)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23763967..23768500)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene minotaur Neighboring gene antisense RNA:CR46452 Neighboring gene Nuclear receptor binding SET domain protein Neighboring gene mitoferrin Neighboring gene Glycoprotein 93 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BOD1 Is Required for Cognitive Function in Humans and Drosophila. Esmaeeli-Nieh S, et al. PLoS Genet, 2016 May. PMID 27166630, Free PMC Article
  2. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587
  3. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. Metzendorf C, et al. BMC Dev Biol, 2010 Jun 21. PMID 20565922, Free PMC Article
  4. Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. Gorsi B, et al. J Clin Endocrinol Metab, 2022 Feb 17. PMID 34718612, Free PMC Article
  5. Minotaur is critical for primary piRNA biogenesis. Vagin VV, et al. RNA, 2013 Aug. PMID 23788724, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in nonassociative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
biorientation defective 1
Names
BOD1-PA
BOD1-PB
BOD1-PC
BOD1-PD
BOD1-PE
CG5514-PA
CG5514-PB
CG5514-PC
CG5514-PD
CG5514-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27938245..27942778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143342.2 → NP_651599.1  biorientation defective 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651599.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMM6
    Related
    FBpp0084622
    Conserved Domains (1) summary
    pfam05205
    Location:8 → 102
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  2. NM_001170280.2 → NP_001163751.1  biorientation defective 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163751.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAY4
    Conserved Domains (1) summary
    pfam05205
    Location:8 → 102
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  3. NM_170361.3 → NP_733240.1  biorientation defective 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733240.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAY4
    Related
    FBpp0084621
    Conserved Domains (1) summary
    pfam05205
    Location:8 → 102
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  4. NM_001276102.1 → NP_001263031.1  biorientation defective 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263031.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHZ9
    Conserved Domains (1) summary
    pfam05205
    Location:8 → 102
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  5. NM_001276101.1 → NP_001263030.1  biorientation defective 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263030.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMM6
    Conserved Domains (1) summary
    pfam05205
    Location:8 → 102
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHZ9 A0A0B4KHZ9
Q8IMM6 Q8IMM6
Q8MRP6 Q8MRP6
Q9VAY4 Q9VAY4

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