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unc80 uncoordinated 80 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43324, updated on 4-Jan-2025

Summary

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Official Symbol
unc80provided by FlyBase
Official Full Name
uncoordinated 80provided by FlyBase
Primary source
FLYBASE:FBgn0039536
Locus tag
Dmel_CG18437
See related
AllianceGenome:FB:FBgn0039536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18437; Dmel\CG18437; Dunc80; UNC80
Summary
Predicted to enable monoatomic cation channel activity. Involved in locomotor rhythm. Part of cation channel complex. Is expressed in adult head and spermatozoon. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See unc80 in Genome Data Viewer
Location:
98A15-98B1; 3-94 cM
Exon count:
30
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27662439..27677099)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23488161..23502821)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tau Neighboring gene Ribosomal protein S10a Neighboring gene Myosin alkali light chain 1 Neighboring gene Hydroxysteroid dehydrogenase like 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79. Murakami K, et al. G3 (Bethesda), 2021 Aug 7. PMID 34849820, Free PMC Article
  2. UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. Lear BC, et al. PLoS One, 2013. PMID 24223770, Free PMC Article
  3. New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN. Monteil A, et al. Physiol Rev, 2024 Jan 1. PMID 37615954
  4. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Flourakis M, et al. Cell, 2015 Aug 13. PMID 26276633, Free PMC Article
  5. Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals. Ghezzi A, et al. Front Mol Neurosci, 2014. PMID 24639627, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NA, UNC79, and UNC80 function together in circadian clock neurons to promote rhythmic behavior.
    Title: UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cation channel complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cation channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncoordinated 80
Names
CG18437-PC
CG18437-PD
CG18437-PE
CG18437-PF
CG18437-PG
unc80-PC
unc80-PD
unc80-PE
unc80-PF
unc80-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27662439..27677099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276095.1 → NP_001263024.1  uncoordinated 80, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHR1
    Conserved Domains (2) summary
    pfam15778
    Location:51 → 260
    UNC80; Cation channel complex component UNC80
    pfam17061
    Location:3069 → 3225
    PARM; PARM

  2. NM_001276094.1 → NP_001263023.1  uncoordinated 80, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263023.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH56
    Conserved Domains (2) summary
    pfam15778
    Location:51 → 260
    UNC80; Cation channel complex component UNC80
    pfam17061
    Location:3046 → 3202
    PARM; PARM

  3. NM_143320.4 → NP_651577.4  uncoordinated 80, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651577.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VB11
    Conserved Domains (2) summary
    pfam15778
    Location:51 → 260
    UNC80; Cation channel complex component UNC80
    pfam17061
    Location:3040 → 3196
    PARM; PARM

  4. NM_001276096.1 → NP_001263025.1  uncoordinated 80, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263025.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI46
    Conserved Domains (2) summary
    pfam15778
    Location:51 → 260
    UNC80; Cation channel complex component UNC80
    pfam17061
    Location:3040 → 3196
    PARM; PARM

  5. NM_001276093.1 → NP_001263022.1  uncoordinated 80, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHA4
    Conserved Domains (2) summary
    pfam15778
    Location:51 → 260
    UNC80; Cation channel complex component UNC80
    pfam17061
    Location:3016 → 3177
    PARM; PARM
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH56 A0A0B4KH56
A0A0B4KHA4 A0A0B4KHA4
A0A0B4KHR1 A0A0B4KHR1
A0A0B4KI46 A0A0B4KI46
Q9VB11.5 Q9VB11

Gene LinkOut

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