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Cyp6a18 Cytochrome P450 6a18 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43304, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp6a18provided by FlyBase
Official Full Name
Cytochrome P450 6a18provided by FlyBase
Primary source
FLYBASE:FBgn0039519
Locus tag
Dmel_CG13977
See related
AllianceGenome:FB:FBgn0039519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6a18; CG13977; cyp6a18; Cyp6A18; CYP6a18; Dmel\CG13977
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; amnioserosa; embryonic Malpighian tubule; embryonic/larval Malpighian tubule; and yolk nucleus. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; essential hypertension; familial Mediterranean fever; and leukemia (multiple). Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Cyp6a18 in Genome Data Viewer
Location:
98A2-98A2; 3-94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27478675..27482904)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23304397..23308626)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 98a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration. Na D, et al. Mol Syst Biol, 2023 Dec 6. PMID 37984409, Free PMC Article
  2. Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Picchio L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525904
  3. Anti-ageing effects of red ginseng on female Drosophila melanogaster. Hou W, et al. J Cell Mol Med, 2020 Mar. PMID 32022406, Free PMC Article
  4. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226
  5. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 6a18
Names
CG13977-PA
CG13977-PB
Cyp6a18-PA
Cyp6a18-PB
cytochrome P450
NP_001287562.1
NP_651563.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27478675..27482904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300633.1 → NP_001287562.1  cytochrome P450 6a18, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287562.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VB31
    UniProtKB/TrEMBL
    A0A0B4LHU5
    Conserved Domains (1) summary
    pfam00067
    Location:38 → 504
    p450; Cytochrome P450

  2. NM_143306.3 → NP_651563.1  cytochrome P450 6a18, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VB31
    UniProtKB/TrEMBL
    A0A0B4LHU5
    Related
    FBpp0084553
    Conserved Domains (1) summary
    pfam00067
    Location:38 → 504
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHU5 A0A0B4LHU5
Q9VB31.1 Q9VB31

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