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eater eater [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43262, updated on 9-Dec-2024

Summary

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Official Symbol
eaterprovided by FlyBase
Official Full Name
eaterprovided by FlyBase
Primary source
FLYBASE:FBgn0243514
Locus tag
Dmel_CG6124
See related
AllianceGenome:FB:FBgn0243514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C901-like; CG6124; CT19227; Dmel\CG6124; Dmel_CG6124; Eater
Summary
Enables peptidoglycan binding activity and scavenger receptor activity. Involved in several processes, including defense response to Gram-positive bacterium; phagocytosis, recognition; and positive regulation of phagocytosis. Located in cell surface. Is expressed in several structures, including cortical zone of lymph gland primary lobe; embryonic/larval lymph gland; hemocyte; and prohemocyte. Used to study bacterial infectious disease. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See eater in Genome Data Viewer
Location:
97E2-97E2; 3-92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27095867..27099679, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22921589..22925401, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Juvenile hormone binding protein 11 Neighboring gene Carbonic anhydrase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater. Chung YS, et al. J Biol Chem, 2011 Jul 29. PMID 21613218, Free PMC Article
  2. Phagocytosis of bacterial pathogens. Chung YS, et al. Fly (Austin), 2012 Jan-Mar. PMID 22223092, Free PMC Article
  3. Haplotype structure and expression divergence at the Drosophila cellular immune gene eater. Juneja P, et al. Mol Biol Evol, 2010 Oct. PMID 20444883, Free PMC Article
  4. The fliR gene contributes to the virulence of S. marcescens in a Drosophila intestinal infection model. Sina Rahme B, et al. Sci Rep, 2022 Feb 23. PMID 35197500, Free PMC Article
  5. Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance. Cabrera K, et al. PLoS Pathog, 2023 Aug. PMID 37566589, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.
    Title: Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.
  2. Rsults suggest that cationic antimicrobial peptides, as well as lysozymes, can facilitate Eater binding to live Gram-negative bacteria.
    Title: Phagocytosis of bacterial pathogens.
  3. Serpent regulates eater expression by binding to GATA sites.
    Title: Transcriptional regulation of eater gene expression in Drosophila blood cells.
  4. Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater.
    Title: Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater.
  5. CG6124 is the newly-named gene, eater. It is a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.
    Title: Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables scavenger receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis, recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eater
Names
CG6124-PC
eater-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27095867..27099679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143276.3 → NP_651533.3  eater [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651533.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB78
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB78 Q9VB78

Gene LinkOut

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