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Lerp - lysosomal enzyme receptor protein

Predicted to enable insulin-like growth factor binding activity. Involved in lysosomal transport; positive regulation of autophagy; and post-Golgi vesicle-mediated transport. Located in clathrin-coated vesicle; perinuclear region of cytoplasm; and trans-Golgi network. Is expressed in adult brain; adult head; and adult pars intercerebralis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa