Pdf Pigment-dispersing factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pdfprovided by FlyBase
Official Full Name: Pigment-dispersing factorprovided by FlyBase
Primary source: FLYBASE:FBgn0023178
Locus tag: Dmel_CG6496
See related: AllianceGenome:FB:FBgn0023178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.261; anon-WO0140519.3; BcDNA:RH08487; CG6496; cPDH; Dmel\CG6496; Drm-pdf; Drm-PDF; Drm-PDH; PAP; pdf; PDF; PDF C7; PDH
Summary: Enables signaling receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in extracellular space; neuron projection; and neuronal cell body. Is expressed in several structures, including Pdf neurons; accessory medulla; larval midline neurons; pacemaker neurons; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 97B3-97B3; 3-91 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26455462..26456141, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22281184..22281863, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neuropeptide pigment-dispersing factor signals independently of Bruchpilot-labelled active zones in daily remodelled terminals of Drosophila clock neurons.
Title: The neuropeptide pigment-dispersing factor signals independently of Bruchpilot-labelled active zones in daily remodelled terminals of Drosophila clock neurons.
In vivo characterization of the maturation steps of a pigment dispersing factor neuropeptide precursor in the Drosophila circadian pacemaker neurons.
Title: In vivo characterization of the maturation steps of a pigment dispersing factor neuropeptide precursor in the Drosophila circadian pacemaker neurons.
Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes.
Title: Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes.
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance.
Title: Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance.
Regulation of Olfactory Associative Memory by the Circadian Clock Output Signal Pigment-Dispersing Factor (PDF).
Title: Regulation of Olfactory Associative Memory by the Circadian Clock Output Signal Pigment-Dispersing Factor (PDF).
A Homeobox Transcription Factor Scarecrow (SCRO) Negatively Regulates Pdf Neuropeptide Expression through Binding an Identified cis-Acting Element in Drosophila melanogaster.
Title: A Homeobox Transcription Factor Scarecrow (SCRO) Negatively Regulates Pdf Neuropeptide Expression through Binding an Identified cis-Acting Element in Drosophila melanogaster.
Circadian and Genetic Modulation of Visually-Guided Navigation in Drosophila Larvae.
Title: Circadian and Genetic Modulation of Visually-Guided Navigation in Drosophila Larvae.
Light-Mediated Circuit Switching in the Drosophila Neuronal Clock Network.
Title: Light-Mediated Circuit Switching in the Drosophila Neuronal Clock Network.
The authors determined that PDF and DH31 hierarchically function to regulate free-running rhythmicity by acting on the same clock cells (DN1ps). These neuropeptides appear to play important roles in modulating the clock networks involved in free-running rhythmicity.
Title: Neuropeptides PDF and DH31 hierarchically regulate free-running rhythmicity in Drosophila circadian locomotor activity.
Our results indicate that PDF and sNPF inhibit reproductive dormancy by maintaining the insulin producing cells in an active state.
Title: Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in circadian sleep/wake cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eclosion rhythm	TAS Traceable Author Statement more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in locomotor rhythm	TAS Traceable Author Statement more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotor rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to paraquat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Pigment-dispersing factor

Names: CG6496-PA; PDF-associated peptide; PDF-precursor PDF-associated peptide; PIGMENT DISPERSING FACTOR; Pdf-PA; Pigment-dispersing hormone-like peptide; pigment dispersing hormone; pigment dispersion factor; pigment-dispersing hormone

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

26455462..26456141 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079793.3 → NP_524517.1 Pigment-dispersing factor [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524517.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O96690, Q7JYY1, Q9VBE9

UniProtKB/TrEMBL

A0A1B2AL20

Related

FBpp0084396

Conserved Domains (1) summary

pfam06324
Location:83 → 100

Pigment_DH; Pigment-dispersing hormone (PDH)