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osy oskyddad [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43186, updated on 4-Jan-2025

Summary

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Official Symbol
osyprovided by FlyBase
Official Full Name
oskyddadprovided by FlyBase
Primary source
FLYBASE:FBgn0053970
Locus tag
Dmel_CG33970
See related
AllianceGenome:FB:FBgn0053970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14559; CG31085; CG33970; CG6162; CG6166; DmCG33970; Dmel\CG33970; Osy
Summary
Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Located in apical plasma membrane. Is expressed in several structures, including adult fat body; adult head; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. Used to study autosomal recessive congenital ichthyosis. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See osy in Genome Data Viewer
Location:
97A8-97A10; 3-90 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26318355..26362588)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22144077..22188310)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44321 Neighboring gene Aldolase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42765 Neighboring gene Nilkantha Neighboring gene pickpocket 15 Neighboring gene Aldolase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in Drosophila melanogaster. Wang Y, et al. PLoS Genet, 2020 Jan. PMID 31929524, Free PMC Article
  2. Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing. Macdonald SJ, et al. Genetics, 2022 Mar 3. PMID 35100395, Free PMC Article
  3. Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier in Drosophila suzukii and Drosophila melanogaster. Wang Y, et al. Front Genet, 2020. PMID 32849846, Free PMC Article
  4. Toxicological Study and Genetic Basis of BTEX Susceptibility in Drosophila melanogaster. Adebambo TH, et al. Front Genet, 2020. PMID 33193742, Free PMC Article
  5. Toxicity of Dithiothreitol (DTT) to Drosophila melanogaster. Wang Y, et al. Toxicol Rep, 2021. PMID 33425686, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oskyddad
Names
CG33970-PA
CG33970-PB
CG33970-PC
osy-PA
osy-PB
osy-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26318355..26362588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300613.1 → NP_001287542.1  oskyddad, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P18
    Conserved Domains (4) summary
    COG1131
    Location:54 → 321
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam01061
    Location:581 → 738
    ABC2_membrane; ABC-2 type transporter
    pfam12698
    Location:394 → 770
    ABC2_membrane_3; ABC-2 family transporter protein
    cl21455
    Location:48 → 270
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001038982.2 → NP_001034071.1  oskyddad, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034071.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P18
    Conserved Domains (4) summary
    COG1131
    Location:54 → 321
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam01061
    Location:581 → 738
    ABC2_membrane; ABC-2 type transporter
    pfam12698
    Location:394 → 770
    ABC2_membrane_3; ABC-2 family transporter protein
    cl21455
    Location:48 → 270
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001038981.2 → NP_001034070.1  oskyddad, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBF7
    Conserved Domains (2) summary
    pfam01061
    Location:322 → 479
    ABC2_membrane; ABC-2 type transporter
    pfam12698
    Location:135 → 511
    ABC2_membrane_3; ABC-2 family transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86P18 Q86P18
Q95U16 Q95U16
Q9VBF7 Q9VBF7

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