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mpp2b MAGUK p55 scaffold protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 431770, updated on 9-Dec-2024

Summary

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Official Symbol
mpp2bprovided by ZNC
Official Full Name
MAGUK p55 scaffold protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-70
See related
Ensembl:ENSDARG00000010957 AllianceGenome:ZFIN:ZDB-GENE-040704-70
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mpp2; zgc:92011
Summary
Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in basal plate midbrain region; nervous system; and pronephric duct. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See mpp2b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10199214..10300092, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10161371..10262249, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D2 Neighboring gene proteasome 26S subunit, ATPase 5 Neighboring gene peptide YYb Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Sundström G, et al. Gen Comp Endocrinol, 2008 Feb 1. PMID 17950734
  2. Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Wu VM, et al. Development, 2007 Mar. PMID 17267446, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAGUK p55 subfamily member 2b
Names
membrane palmitoylated protein 2b
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2b)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002223.1 → NP_001002223.1  MAGUK p55 subfamily member 2b

    See identical proteins and their annotated locations for NP_001002223.1

    Status: PROVISIONAL

    Source sequence(s)
    BC074066
    UniProtKB/TrEMBL
    Q6GMI2
    Related
    ENSDARP00000109525.2, ENSDART00000126428.4
    Conserved Domains (5) summary
    cd12037
    Location:225 → 283
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:354 → 532
    GuKc; Guanylate kinase homologues
    cd00992
    Location:134 → 212
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:344 → 532
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:62 → 113
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    10199214..10300092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306494.3 → XP_009304769.1  MAGUK p55 subfamily member 2b isoform X3

    UniProtKB/TrEMBL
    A0A8M3AY34
    Conserved Domains (5) summary
    cd12037
    Location:239 → 297
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:345 → 523
    GuKc; Guanylate kinase homologues
    cd00992
    Location:148 → 226
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:335 → 523
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:76 → 127
    L27; L27 domain

  2. XM_009306493.4 → XP_009304768.1  MAGUK p55 subfamily member 2b isoform X2

    UniProtKB/TrEMBL
    A0A8M3BE13
    Conserved Domains (5) summary
    cd12037
    Location:239 → 297
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:363 → 541
    GuKc; Guanylate kinase homologues
    cd00992
    Location:148 → 226
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:353 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:76 → 127
    L27; L27 domain

  3. XM_005156066.5 → XP_005156123.1  MAGUK p55 subfamily member 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2Q1
    Conserved Domains (5) summary
    cd12037
    Location:239 → 297
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:368 → 546
    GuKc; Guanylate kinase homologues
    cd00992
    Location:148 → 226
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:358 → 546
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:76 → 127
    L27; L27 domain
Nucleotide Protein Strain
Heading Accession and Version

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