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PIG-P Phosphatidylinositol glycan anchor biosynthesis class P [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43168, updated on 4-Jan-2025

Summary

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Official Symbol
PIG-Pprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Pprovided by FlyBase
Primary source
FLYBASE:FBgn0039405
Locus tag
Dmel_CG14550
See related
AllianceGenome:FB:FBgn0039405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM30016; CG14550; Dmel\CG14550; Dromel_CG14550_FBtr0084974_mORF; PIGP
Summary
Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Orthologous to human PIGP (phosphatidylinositol glycan anchor biosynthesis class P). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See PIG-P in Genome Data Viewer
Location:
96F10-96F10; 3-89 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26057347..26058223, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21883069..21883945, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytidine/uridine monophosphate kinase 1 Neighboring gene Sld5 Neighboring gene uncharacterized protein Neighboring gene Threonyl-carbamoyl synthesis 6 Neighboring gene Ribosomal protein L34a Neighboring gene tRNA methyltransferase 61 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  2. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  3. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. Hayden CA, et al. BMC Genomics, 2008 Feb 1. PMID 18237443, Free PMC Article
  4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
  5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class P
Names
CG14550-PA
PIG-P-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26057347..26058223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143202.1 → NP_651459.2  phosphatidylinositol glycan anchor biosynthesis class P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651459.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSE4, Q9VBH9
    Related
    FBpp0084347, FBtr0084974
    Conserved Domains (1) summary
    pfam08510
    Location:11 → 157
    PIG-P; PIG-P
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSE4 Q8MSE4

Gene LinkOut

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