E(spl)m3-HLH Enhancer of split m3, helix-loop-helix [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: E(spl)m3-HLHprovided by FlyBase
Official Full Name: Enhancer of split m3, helix-loop-helixprovided by FlyBase
Primary source: FLYBASE:FBgn0002609
Locus tag: Dmel_CG8346
See related: AllianceGenome:FB:FBgn0002609
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHc14; CG8346; Dmel\CG8346; E(spl)-C; E(Spl)-HLH-m3; E(spl)-m3; E(spl)C; E(spl)C m3; E(spl)m3; E(spl)M3; HLH-m3; HLHm3; HLHM3; m3
Summary: Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of neuroblast proliferation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; germ layer; gut section; and head epidermis primordium. Orthologous to human HES2 (hes family bHLH transcription factor 2) and HES4 (hes family bHLH transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26021823..26023127)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21847545..21848849)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

Names: CG8346-PA; E(spl) region transcript m3; E(spl)m3-HLH-PA; enhancer of split m3; split locus enhancer protein m3

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The following sections contain reference sequences that belong to a specific genome build. Explain