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CG31089 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43135, updated on 4-Jan-2025

Summary

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Official Symbol
CG31089provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051089
Locus tag
Dmel_CG31089
See related
AllianceGenome:FB:FBgn0051089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5990; Dmel\CG31089
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG31089 in Genome Data Viewer
Location:
96F7-96F7; 3-89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25902643..25904178)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21728365..21729900)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43259 Neighboring gene Multicopper oxidase 3 Neighboring gene uncharacterized protein Neighboring gene kin of rumpel Neighboring gene uncharacterized protein Neighboring gene Crustacean cardioactive peptide receptor Neighboring gene long non-coding RNA:CR34024

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. Subramanian M, et al. Dis Model Mech, 2013 May. PMID 23471909, Free PMC Article
  2. ATF4 Responds to Metabolic Stress in Drosophila. Ok S, et al. Front Biosci (Landmark Ed), 2023 Dec 26. PMID 38179767
  3. Control of lipid metabolism by tachykinin in Drosophila. Song W, et al. Cell Rep, 2014 Oct 9. PMID 25263556, Free PMC Article
  4. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Vonolfen MC, et al. Cell Rep, 2024 Sep 24. PMID 39235946
  5. Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster. Rajpurohit S, et al. Mol Ecol, 2018 Sep. PMID 30051644, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG31089-PA
NP_733128.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25902643..25904178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170249.2 → NP_733128.1  uncharacterized protein Dmel_CG31089 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733128.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBK6
    Related
    FBpp0084316
    Conserved Domains (2) summary
    pfam04083
    Location:48 → 110
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    cl21494
    Location:86 → 237
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBK6 Q9VBK6

Gene LinkOut

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