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Sodq Sodesque [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43133, updated on 9-Dec-2024

Summary

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Official Symbol
Sodqprovided by FlyBase
Official Full Name
Sodesqueprovided by FlyBase
Primary source
FLYBASE:FBgn0039386
Locus tag
Dmel_CG5948
See related
AllianceGenome:FB:FBgn0039386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5948; Dmel\CG5948; SOD
Summary
Predicted to enable copper ion binding activity. Predicted to be involved in superoxide metabolic process. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Sodq in Genome Data Viewer
Location:
96F6-96F7; 3-89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25895822..25897174)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21721544..21722896)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Lnk Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Superoxide dismutase evolution and life span regulation. Landis GN, et al. Mech Ageing Dev, 2005 Mar. PMID 15664623
  2. Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera). Hewitt OH, et al. BMC Biol, 2022 Sep 30. PMID 36175868, Free PMC Article
  3. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
  4. Fatty acid tryptamide from cacao elongates Drosophila melanogaster lifespan with sirtuin-dependent heat shock protein expression. Kanno K, et al. Sci Rep, 2022 Jul 15. PMID 35840713, Free PMC Article
  5. Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. Fabian DK, et al. Mol Ecol, 2012 Oct. PMID 22913798, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables superoxide dismutase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodesque
Names
CG5948-PA
CG5948-PB
Sodq-PA
Sodq-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25895822..25897174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143183.2 → NP_651440.1  sodesque, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBK8
    Related
    FBpp0084313
    Conserved Domains (1) summary
    pfam00080
    Location:108 → 243
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

  2. NM_001260377.1 → NP_001247306.1  sodesque, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247306.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K763
    Conserved Domains (1) summary
    pfam00080
    Location:107 → 242
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K763 A0A0B4K763
Q9VBK8 Q9VBK8

Gene LinkOut

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