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alpha4GT2 alpha1,4-galactosyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43124, updated on 4-Jan-2025

Summary

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Official Symbol
alpha4GT2provided by FlyBase
Official Full Name
alpha1,4-galactosyltransferase 2provided by FlyBase
Primary source
FLYBASE:FBgn0039378
Locus tag
Dmel_CG5878
See related
AllianceGenome:FB:FBgn0039378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5878; Dmel\CG5878
Summary
Enables alpha-1,4-N-acetylgalactosaminyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in membrane. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)) and A4GNT (alpha-1,4-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See alpha4GT2 in Genome Data Viewer
Location:
96F3-96F3; 3-89 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25832230..25842878)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21657952..21668600)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Male-specific RNA 57Db Neighboring gene Male-specific RNA 57Da Neighboring gene long non-coding RNA:CR45653 Neighboring gene long non-coding RNA:CR45654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster homologue of the human histo-blood group Pk gene encodes a glycolipid-modifying alpha1,4-N-acetylgalactosaminyltransferase. Mucha J, et al. Biochem J, 2004 Aug 15. PMID 15130086, Free PMC Article
  2. Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila. Chen YW, et al. Dev Biol, 2007 Jun 15. PMID 17498683
  3. Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster. Hamel S, et al. J Cell Biol, 2010 Feb 22. PMID 20176925, Free PMC Article
  4. Roles of sphingolipids in Drosophila development and disease. Kraut R. J Neurochem, 2011 Mar. PMID 21214556
  5. Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. Schrider DR, et al. Genome Res, 2011 Dec. PMID 22135405, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 25832746-25841869 mobile_element_type = transposon:roo{}alpha4GT2[1]

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,4-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,4-N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycosphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alpha1,4-galactosyltransferase 2
Names
CG5878-PB
alpha4GT2-PB
NP_651434.3
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25832230..25842878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143177.4 → NP_651434.3  alpha1,4-galactosyltransferase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651434.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBL5
    Conserved Domains (2) summary
    pfam04572
    Location:265 → 391
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
    cl19952
    Location:129 → 241
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBL5 Q9VBL5

Gene LinkOut

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