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CG4743 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43101, updated on 4-Jan-2025

Summary

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Official Symbol
CG4743provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039357
Locus tag
Dmel_CG4743
See related
AllianceGenome:FB:FBgn0039357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4743; Samc
Summary
Predicted to enable S-adenosyl-L-methionine transmembrane transporter activity. Predicted to be involved in S-adenosyl-L-methionine transport. Predicted to be active in mitochondrial inner membrane. Used to study combined oxidative phosphorylation deficiency 28. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG4743 in Genome Data Viewer
Location:
96E9-96E9; 3-88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25679242..25680550, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21504964..21506272, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 3 Neighboring gene long non-coding RNA:CR45225 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27 Neighboring gene Cardiolipin synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters. Rosenberger FA, et al. Sci Adv, 2021 Feb. PMID 33608280, Free PMC Article
  2. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
  3. 52 Genetic Loci Influencing Myocardial Mass. van der Harst P, et al. J Am Coll Cardiol, 2016 Sep 27. PMID 27659466, Free PMC Article
  4. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
  5. Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits. Kanellopoulos AK, et al. Cell, 2020 Mar 19. PMID 32200800

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-adenosyl-L-methionine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosyl-L-methionine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in S-adenosyl-L-methionine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4743-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25679242..25680550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143158.2 → NP_651415.1  uncharacterized protein Dmel_CG4743 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651415.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V4S1, Q9VBN7
    Related
    FBpp0084307
    Conserved Domains (2) summary
    PTZ00168
    Location:25 → 281
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:199 → 291
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBN7.2 Q9VBN7

Gene LinkOut

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