ND-49L NADH dehydrogenase (ubiquinone) 49 kDa subunit-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-49Lprovided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) 49 kDa subunit-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0039331
Locus tag: Dmel_CG11913
See related: AllianceGenome:FB:FBgn0039331
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG111913; CG11913; Dmel\CG11913; dNDUFS2B; NUCM; Q9VBR4_DROME
Summary: Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25358285..25360034)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21184007..21185756)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	NAS Non-traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info

Names: CG11913-PB; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH:ubiquinone oxidoreductase 49 kDa subunit; ND-49L-PB

NP_651392.2

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The following sections contain reference sequences that belong to a specific genome build. Explain