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Clbn Caliban [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43018, updated on 9-Dec-2024

Summary

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Official Symbol
Clbnprovided by FlyBase
Official Full Name
Calibanprovided by FlyBase
Primary source
FLYBASE:FBgn0259152
Locus tag
Dmel_CG11847
See related
AllianceGenome:FB:FBgn0259152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11847; clbn; Dmel\CG11847; NEMF
Summary
Enables tRNA binding activity. Involved in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; protein export from nucleus; and rescue of stalled ribosome. Located in cytoplasmic side of mitochondrial outer membrane. Is expressed in adult head. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Clbn in Genome Data Viewer
Location:
96C1-96C1; 3-87 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25127502..25131155)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20953224..20956877)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene vig2 Neighboring gene Molybdenum cofactor synthesis 2B Neighboring gene Molybdenum cofactor synthesis 2A Neighboring gene Band4.1 inhibitor LRP interactor Neighboring gene long non-coding RNA:CR46098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity. Wang Y, et al. Oncogene, 2013 Aug 15. PMID 22964637
  2. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Bi X, et al. Oncogene, 2005 Dec 15. PMID 16103875
  3. RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease. Li Y, et al. J Biol Chem, 2024 Mar. PMID 38311171, Free PMC Article
  4. Birth of a new gene on the Y chromosome of Drosophila melanogaster. Carvalho AB, et al. Proc Natl Acad Sci U S A, 2015 Oct 6. PMID 26385968, Free PMC Article
  5. Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint. Song F, et al. Cell Cycle, 2018. PMID 30231800, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes.
    Title: Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes.
  2. Induced expression of clbn suppressed E2F1 activity and down-regulates the DNA replication and expression of its downstream target cyclin E, a key regulator of G1-to-S transition.
    Title: Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint.
  3. We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways.
    Title: The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity.
  4. Expression of fly caliban in human lung cancer cells restores non-functional nuclear export of lung cancer cells, impairs a cell's ability to form colonies on soft agar and reduces cell invasiveness
    Title: Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CAT tailing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caliban
Names
CG11847-PB
CG11847-PC
Clbn-PB
Clbn-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25127502..25131155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143084.2 → NP_651341.2  caliban, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651341.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E6Q0, Q9VBX1
    UniProtKB/TrEMBL
    D2NUI9
    Conserved Domains (3) summary
    COG1293
    Location:1 → 643
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:531 → 630
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:883 → 984
    DUF3441; Domain of unknown function (DUF3441)

  2. NM_001170250.1 → NP_001163721.1  caliban, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E6Q0, Q9VBX1
    UniProtKB/TrEMBL
    D2NUI9
    Conserved Domains (3) summary
    COG1293
    Location:1 → 643
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:531 → 630
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:883 → 984
    DUF3441; Domain of unknown function (DUF3441)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBX1.2 Q9VBX1

Gene LinkOut

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