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TTLL5 Tubulin tyrosine ligase-like 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43015, updated on 9-Dec-2024

Summary

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Official Symbol
TTLL5provided by FlyBase
Official Full Name
Tubulin tyrosine ligase-like 5provided by FlyBase
Primary source
FLYBASE:FBgn0051108
Locus tag
Dmel_CG31108
See related
AllianceGenome:FB:FBgn0051108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10057; CG31108; DmCG31108; Dmel\CG31108; DmTTLL5
Summary
Enables tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in ciliary basal body. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; ganglia; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See TTLL5 in Genome Data Viewer
Location:
96C1-96C1; 3-87 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25112867..25122920, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20938589..20948642, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 16 Neighboring gene uncharacterized protein Neighboring gene vig2 Neighboring gene Molybdenum cofactor synthesis 2B Neighboring gene Molybdenum cofactor synthesis 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System. Devambez I, et al. Sci Rep, 2017 Nov 24. PMID 29176602, Free PMC Article
  2. Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo. Bao M, et al. Elife, 2023 Jun 22. PMID 37345829, Free PMC Article
  3. Predicting gene regulatory interactions based on spatial gene expression data and deep learning. Yang Y, et al. PLoS Comput Biol, 2019 Sep. PMID 31527870, Free PMC Article
  4. Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. Gorsi B, et al. J Clin Endocrinol Metab, 2022 Feb 17. PMID 34718612, Free PMC Article
  5. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TTLL5 was identified as a major tubulin glutamylase in Drosophila neurons.
    Title: Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulin tyrosine ligase-like 5
Names
CG31108-PA
CG31108-PB
TTLL5-PA
TTLL5-PB
NP_001287520.1
NP_733081.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25112867..25122920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170202.3 → NP_733081.1  tubulin tyrosine ligase-like 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBX5
    Related
    FBpp0084177
    Conserved Domains (1) summary
    pfam03133
    Location:266 → 549
    TTL; Tubulin-tyrosine ligase family

  2. NM_001300591.1 → NP_001287520.1  tubulin tyrosine ligase-like 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287520.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBX5
    Conserved Domains (1) summary
    pfam03133
    Location:266 → 549
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBX5 Q9VBX5

Gene LinkOut

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