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shams shams [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43008, updated on 9-Dec-2024

Summary

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Official Symbol
shamsprovided by FlyBase
Official Full Name
shamsprovided by FlyBase
Primary source
FLYBASE:FBgn0039273
Locus tag
Dmel_CG9996
See related
AllianceGenome:FB:FBgn0039273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9996; dibeta3GnT5; Dmel\CG9996; Shams
Summary
Enables protein xylosyltransferase activity. Involved in negative regulation of Notch signaling pathway and protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including GXYLT1 (glucoside xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See shams in Genome Data Viewer
Location:
96B20-96B20; 3-86 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25072729..25074607, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20898451..20900329, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene forkhead domain 96Ca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Meeting Between Rumi and Shams in Notch Signaling; Implications for Pain Management: A Narrative Review. Rajaei S, et al. Anesth Pain Med, 2019 Feb. PMID 30881911, Free PMC Article
  2. Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila. Lee TV, et al. PLoS Genet, 2017 Apr. PMID 28394891, Free PMC Article
  3. Negative regulation of notch signaling by xylose. Lee TV, et al. PLoS Genet, 2013 Jun. PMID 23754965, Free PMC Article
  4. Significant Roles of Notch O-Glycosylation in Cancer. Wang W, et al. Molecules, 2022 Mar 9. PMID 35335147, Free PMC Article
  5. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. Harvey BM, et al. J Biol Chem, 2016 Jul 29. PMID 27268051, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-xylosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein xylosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in O-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
shams
Names
CG9996-PB
shams-PB
NP_001097911.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25072729..25074607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104441.2 → NP_001097911.1  shams [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097911.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBY3
    Conserved Domains (2) summary
    COG1442
    Location:64 → 270
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    cl11394
    Location:48 → 343
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBY3 Q9VBY3

Gene LinkOut

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