Ythdf YTH N6-methyladenosine RNA binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ythdfprovided by FlyBase
Official Full Name: YTH N6-methyladenosine RNA binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0039261
Locus tag: Dmel_CG6422
See related: AllianceGenome:FB:FBgn0039261
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6422; Dmel\CG6422; ythdf; YTHDF
Summary: Enables N6-methyladenosine-containing RNA reader activity and pre-mRNA binding activity. Involved in negative regulation of axon extension. Located in cytoplasm. Is expressed in larval central nervous system; organism; and ventral neurectoderm. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including YTHDF1 (YTH N6-methyladenosine RNA binding protein F1) and YTHDF2 (YTH N6-methyladenosine RNA binding protein F2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25033876..25039249, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20859598..20864971, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila.
Title: A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA destabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

Names: CG6422-PA; CG6422-PB; CG6422-PC; CG6422-PD; Ythdf-PA; Ythdf-PB; Ythdf-PC; Ythdf-PD

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The following sections contain reference sequences that belong to a specific genome build. Explain