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PIG-S Phosphatidylinositol glycan anchor biosynthesis class S [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42979, updated on 9-Dec-2024

Summary

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Official Symbol
PIG-Sprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Sprovided by FlyBase
Primary source
FLYBASE:FBgn0265190
Locus tag
Dmel_CG44255
See related
AllianceGenome:FB:FBgn0265190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13644; CG31120; CG44255; CG6031; Dmel\CG44255; PIGS; sud2
Summary
Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Located in endomembrane system and nucleoplasm. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 95. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See PIG-S in Genome Data Viewer
Location:
96B6-96B6; 3-86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24913216..24917864, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20738938..20743586, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44267 Neighboring gene transfer RNA:Aspartic acid-GTC 1-12 Neighboring gene transfer RNA:Aspartic acid-GTC 3-1 Neighboring gene sudestada1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46097 Neighboring gene Mitotic spindle and nuclear protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
  2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
  3. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Katz MJ, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24550463, Free PMC Article
  4. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  5. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm HDA PubMed 

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class S
Names
CG44255-PC
PIG-S-PC
phosphatidylinositol glycan anchor biosynthesis, class S
phosphatidylinositol glycan anchor biosynthesis, class S ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24913216..24917864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170181.3 → NP_733060.1  phosphatidylinositol glycan anchor biosynthesis class S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A3W8, Q95R26, Q9VC10
    Related
    FBpp0308257
    Conserved Domains (1) summary
    pfam10510
    Location:28 → 521
    PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC10 Q9VC10

Gene LinkOut

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