U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Saf-B Scaffold attachment factor B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42958, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Saf-Bprovided by FlyBase
Official Full Name
Scaffold attachment factor Bprovided by FlyBase
Primary source
FLYBASE:FBgn0039229
Locus tag
Dmel_CG6995
See related
AllianceGenome:FB:FBgn0039229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg6995; CG6995; Dmel\CG6995; LD22822; saf-b; SAF-B; SAFB
Summary
Predicted to enable mRNA binding activity and sequence-specific DNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear matrix and nucleoplasm. Is expressed in several structures, including anterior-posterior subdivision of organism; germline cell; larval brain; larval central nervous system; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including SAFB (scaffold attachment factor B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Saf-B in Genome Data Viewer
Location:
96A23-96A23; 3-85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24817464..24822350)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20643186..20648072)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46096 Neighboring gene uncharacterized protein Neighboring gene nimA-like kinase Neighboring gene long non-coding RNA:CR43166

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila SAF-B links the nuclear matrix, chromosomes, and transcriptional activity. Alfonso-Parra C, et al. PLoS One, 2010 Apr 20. PMID 20422039, Free PMC Article
  2. Dynamics of hnRNPs and omega speckles in normal and heat shocked live cell nuclei of Drosophila melanogaster. Singh AK, et al. Chromosoma, 2015 Sep. PMID 25663367
  3. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
  4. Autonomous transposons tune their sequences to ensure somatic suppression. Ilık İA, et al. Nature, 2024 Feb. PMID 38355802, Free PMC Article
  5. From Heterochromatin to Long Noncoding RNAs in Drosophila: Expanding the Arena of Gene Function and Regulation. Lakhotia SC. Adv Exp Med Biol, 2017. PMID 28815537

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
scaffold attachment factor B
Names
CG6995-PB
CG6995-PD
CG6995-PE
CG6995-PF
Saf-B-PB
Saf-B-PD
Saf-B-PE
Saf-B-PF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24817464..24822350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316518.1 → NP_001303447.1  scaffold attachment factor B, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GV03
    Conserved Domains (1) summary
    pfam02037
    Location:11 → 42
    SAP; SAP domain

  2. NM_001316517.1 → NP_001303446.1  scaffold attachment factor B, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GV03
    Conserved Domains (1) summary
    pfam02037
    Location:11 → 42
    SAP; SAP domain

  3. NM_170169.3 → NP_733041.2  scaffold attachment factor B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733041.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGV1, Q8IMV6
    Related
    FBpp0084078
    Conserved Domains (4) summary
    COG0724
    Location:205 → 394
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12417
    Location:313 → 386
    RRM_SAFB_like; RNA recognition motif in the scaffold attachment factor (SAFB) family
    pfam02037
    Location:11 → 42
    SAP; SAP domain
    pfam16495
    Location:588 → 618
    SWIRM-assoc_1; SWIRM-associated region 1

  4. NM_001276002.1 → NP_001262931.1  scaffold attachment factor B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGV9
    Conserved Domains (1) summary
    pfam02037
    Location:11 → 42
    SAP; SAP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGV9 A0A0B4KGV9
A0A126GV03 A0A126GV03
Q7K1P7 Q7K1P7
Q8IGV1 Q8IGV1
Q8IMV6 Q8IMV6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous