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REPTOR Repressed by TOR [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42930, updated on 4-Jan-2025

Summary

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Official Symbol
REPTORprovided by FlyBase
Official Full Name
Repressed by TORprovided by FlyBase
Primary source
FLYBASE:FBgn0039209
Locus tag
Dmel_CG13624
See related
AllianceGenome:FB:FBgn0039209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.65; CG13624; DM23; DM24; Dmel\CG13624; reptor; Reptor
Summary
Enables protein heterodimerization activity. Involved in TORC1 signaling; positive regulation of DNA-templated transcription; and response to starvation. Located in cytosol and nucleus. Is expressed in several structures, including antennal anlage; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and ventral nerve cord. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See REPTOR in Genome Data Viewer
Location:
96A7-96A9; 3-85 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24557368..24582864, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20383090..20408586, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U6 at 96A b Neighboring gene small nuclear RNA U6 at 96A c Neighboring gene long non-coding RNA:CR46094 Neighboring gene uncharacterized protein Neighboring gene molting defective Neighboring gene long non-coding RNA:CR46095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies. Xu J, et al. Elife, 2022 Jan 25. PMID 35076390, Free PMC Article
  2. The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response. Agrawal N, et al. Cell Metab, 2016 Apr 12. PMID 27076079
  3. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Vandehoef C, et al. Cell Rep, 2020 Jun 9. PMID 32521261, Free PMC Article
  4. The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. Bjedov I, et al. Genes (Basel), 2020 Sep 3. PMID 32899412, Free PMC Article
  5. Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae. Rodríguez-Vázquez M, et al. EMBO Rep, 2024 Oct. PMID 39251827, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. REPTOR and CREBRF encode key regulators of muscle energy metabolism.
    Title: REPTOR and CREBRF encode key regulators of muscle energy metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
repressed by TOR
Names
CG13624-PA
CG13624-PB
CG13624-PC
CG13624-PD
CG13624-PE
CG13624-PF
CG13624-PG
REPTOR-PA
REPTOR-PB
REPTOR-PC
REPTOR-PD
REPTOR-PE
REPTOR-PF
REPTOR-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24557368..24582864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170151.2 → NP_733013.1  repressed by TOR, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733013.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI17, Q8T9A9, Q9VC61
    UniProtKB/TrEMBL
    A0A0B4LHL0
    Related
    FBpp0084052
    Conserved Domains (1) summary
    cd14809
    Location:701 → 747
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  2. NM_170152.2 → NP_733014.1  repressed by TOR, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733014.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI17, Q8T9A9, Q9VC61
    UniProtKB/TrEMBL
    A0A0B4LHL0
    Related
    FBpp0084053
    Conserved Domains (1) summary
    cd14809
    Location:701 → 747
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  3. NM_001043287.2 → NP_001036752.1  repressed by TOR, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036752.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VC61
    Conserved Domains (1) summary
    cd14809
    Location:701 → 756
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  4. NM_001043288.2 → NP_001036753.1  repressed by TOR, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036753.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VC61
    Conserved Domains (1) summary
    cd14809
    Location:701 → 756
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  5. NM_170150.2 → NP_733012.1  repressed by TOR, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733012.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI17, Q8T9A9, Q9VC61
    UniProtKB/TrEMBL
    A0A0B4LHL0
    Related
    FBpp0084054
    Conserved Domains (1) summary
    cd14809
    Location:701 → 747
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  6. NM_143014.3 → NP_651271.1  repressed by TOR, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651271.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI17, Q8T9A9, Q9VC61
    UniProtKB/TrEMBL
    A0A0B4LHL0
    Related
    FBpp0084055
    Conserved Domains (1) summary
    cd14809
    Location:701 → 747
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  7. NM_001300576.1 → NP_001287505.1  repressed by TOR, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287505.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI17, Q8T9A9, Q9VC61
    UniProtKB/TrEMBL
    A0A0B4LHL0
    Conserved Domains (1) summary
    cd14809
    Location:701 → 747
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHL0 A0A0B4LHL0
Q9VC61.2 Q9VC61

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