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Cftr CF transmembrane conductance regulator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42928, updated on 4-Jan-2025

Summary

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Official Symbol
Cftrprovided by FlyBase
Official Full Name
CF transmembrane conductance regulatorprovided by FlyBase
Primary source
FLYBASE:FBgn0039207
Locus tag
Dmel_CG5789
See related
AllianceGenome:FB:FBgn0039207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CFTR; CG5789; DmCG5789; Dmel\CFTR; Dmel\CG5789; Dme_CG5789
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Used to study cystic fibrosis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cftr in Genome Data Viewer
Location:
96A6-96A7; 3-85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24536204..24543914, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20361926..20369636, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Juvenile hormone binding protein 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anastral spindle 1 Neighboring gene Extended synaptotagmin-like protein 2 Neighboring gene transfer RNA:Aspartic acid-GTC 1-11 Neighboring gene small nuclear RNA U6 at 96A a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections. Touré H, et al. Infect Immun, 2023 Nov 16. PMID 37847031, Free PMC Article
  2. Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. Kim K, et al. Proc Natl Acad Sci U S A, 2020 May 12. PMID 32345720, Free PMC Article
  3. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810
  4. Bioelectric regulation of intestinal stem cells. Petsakou A, et al. Trends Cell Biol, 2023 Jul. PMID 36396487, Free PMC Article
  5. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. Mayer F, et al. J Neurosci, 2009 Mar 18. PMID 19295159, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CF transmembrane conductance regulator
Names
CG5789-PA
CG5789-PB
Cftr-PA
Cftr-PB
NP_001247286.1
NP_651269.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24536204..24543914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143012.3 → NP_651269.1  CF transmembrane conductance regulator, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651269.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHL5, Q9VC63
    Related
    FBpp0088845
    Conserved Domains (4) summary
    cd03244
    Location:1135 → 1350
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:495 → 699
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:9 → 1367
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:863 → 1088
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001260357.1 → NP_001247286.1  CF transmembrane conductance regulator, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHL5, Q9VC63
    Conserved Domains (4) summary
    cd03244
    Location:1135 → 1350
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:495 → 699
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:9 → 1367
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:863 → 1088
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC63 Q9VC63

Gene LinkOut

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