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crb - crumbs

Enables protein kinase C binding activity. Involved in several processes, including adherens junction organization; morphogenesis of an epithelium; and respiratory system development. Located in several cellular components, including apicolateral plasma membrane; photoreceptor connecting cilium; and rhabdomere. Is expressed in several structures, including epithelial cell; epithelium; eye photoreceptor cell stalk; gut section; and rhabdomere. Used to study Leber congenital amaurosis and retinitis pigmentosa. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa