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Orct Organic cation transporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42891, updated on 4-Jan-2025

Summary

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Official Symbol
Orctprovided by FlyBase
Official Full Name
Organic cation transporterprovided by FlyBase
Primary source
FLYBASE:FBgn0019952
Locus tag
Dmel_CG6331
See related
AllianceGenome:FB:FBgn0019952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6331; Dmel\CG6331; orct; SLC22A5; SLC22A5/13
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in apoptotic process. Predicted to be located in membrane. Is expressed in several structures, including adult head; amnioserosa; ganglia; gut section; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; acute kidney failure; cardiomyopathy; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Orct in Genome Data Viewer
Location:
95F8-95F8; 3-84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24276260..24278792)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20101982..20104514)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1 Neighboring gene Organic cation transporter 2 Neighboring gene long non-coding RNA:CR45662 Neighboring gene sheepish

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Orct gene of Drosophila melanogaster codes for a putative organic cation transporter with six or 12 transmembrane domains. Taylor CA, et al. Gene, 1997 Nov 12. PMID 9409773
  2. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies. Gai Y, et al. Neuron, 2016 May 4. PMID 27146270, Free PMC Article
  3. Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier. Li F, et al. Elife, 2023 May 4. PMID 37140181, Free PMC Article
  4. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
  5. Hsp27 over expression protect against cadmium induced nephrotoxicity in Drosophila melanogaster. Saini S, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2023 Nov. PMID 37586579

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
organic cation transporter
Names
CG6331-PA
CG6331-PB
Orct-PA
Orct-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24276260..24278792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079755.2 → NP_524479.1  organic cation transporter, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524479.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01383, O01384, Q9VCA2
    UniProtKB/TrEMBL
    A0A0B4KI00, R9QRD4
    Related
    FBpp0083983
    Conserved Domains (2) summary
    cd06174
    Location:135 → 491
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 514
    2A0119; cation transport protein

  2. NM_001275979.1 → NP_001262908.1  organic cation transporter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01383, O01384, Q9VCA2
    UniProtKB/TrEMBL
    A0A0B4KI00, R9QRD4
    Conserved Domains (2) summary
    cd06174
    Location:135 → 491
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 514
    2A0119; cation transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KI00 A0A0B4KI00
Q9VCA2.1 Q9VCA2

Gene LinkOut

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